AIDED - Acute kIDnEy injury in coviD-19.

由冠状病毒(新冠肺炎)引起的大流行虽然主要影响肺部和呼吸道，但也会影响身体的其他器官。在需要住院治疗的新冠肺炎患者中，至少有四分之一的人还会遭受肾功能减退(称为急性肾损伤)，这可能会导致完全的肾功能衰竭。由于新冠肺炎中导致急性肾脏损伤的一些过程是病毒感染特有的，因此长期的肾脏健康可能会受到更严重的影响。目前，我们还不知道新冠肺炎对肾脏的长期影响。提高我们对这一点的理解很重要，使我们能够知道如何最好地监测和支持人们从最初的感染中恢复过来。为了解决这个问题，我们将进行一项独特的研究，将英国诺丁汉大学的科学家和瑞典乌普萨拉大学的科学家聚集在一起。这项研究将收集瑞典乌普萨拉大学(Uppsala University)的急性新冠肺炎呼吸机患者的一些不同的磁共振成像数据集。MRI可以非常详细地显示整个肾脏，并且有一系列MRI技术可以评估肾功能的不同方面。将不同的MRI技术结合到一个单一的扫描过程中称为多参数MRI。多参数核磁共振将评估新冠肺炎可能已在肾脏引起的变化，如血流量、氧气水平和瘢痕形成(纤维化)程度的变化。此外，还将测量肝和脾等其他器官功能的变化。重要的是，MRI扫描不使用辐射(与X光和CT扫描不同)。在新冠肺炎急性期接受扫描的患者将在住院3个月和12个月后再次收集核磁共振测量数据。在瑞典收集的多参数核磁共振测量数据将由北卡罗来纳大学的专家进行分析，并与现有的核磁共振数据集进行比较，这些数据包括新冠肺炎爆发前在北大大学收集的非冠状病毒AKI，以及来自北大和北大的健康受试者。这些信息来源将让我们了解新冠肺炎对肾脏的长期影响。这将告知新冠肺炎如何影响患者的肾脏健康，以及应该如何监测。

The pandemic caused by the Coronavirus (COVID-19) although primarily affecting the lungs and airways, affects other organs in the body. At least a quarter of people who need hospital treatment for COVID-19 also suffer reduced kidney function (known as acute kidney injury, AKI), which can cause complete kidney failure. As some of the processes that lead to AKI in COVID-19 are specific to the viral infection, it is possible that long term kidney health may be more severely affected. At the moment, we do not know the long-term effects of COVID-19 on the kidneys. Improving our understanding of this is important to allow us to know how best to monitor and support people after their recovery from the initial infection. To address this, we will perform a unique research study that will bring together scientists at the University of Nottingham, UK and those in Uppsala University, Sweden. The study will collect a number of different Magnetic Resonance Imaging (MRI) datasets in ventilated patients with acute COVID-19 in Uppsala University (UU), Sweden. MRI can show the entire kidney in great detail and there is a range of MRI techniques that can assess different aspects of kidney function. Combining the different MRI techniques into a single scan session is called multiparametric MRI. Multiparametric MRI will assess the changes that may have been caused by COVID-19 in the kidneys, such as changes in blood flow, oxygen levels and the degree of scarring (fibrosis). In addition, changes in other organ function such as the liver and spleen will be measured. Importantly, MRI scans do not use radiation (unlike X-Rays and CT scans). Patients scanned at the acute phase of COVID-19 will have their MRI measures collected again at 3 and 12 months after being in hospital.The multiparametric MRI measures collected in Sweden will be analysed by experts at UoN and compared to an existing MRI dataset of non-COVID AKI collected at the UoN, prior to the COVID-19 outbreak, and healthy subjects from both the UoN and UU. These information sources will allow us to understand the long-term effects of COVID-19 on the kidneys. This will inform how COVID-19 is impacting patients' kidney health, and how this should be monitored.