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MOLECULAR GENETIC INTERVENTION FOR AIDS--TRANSDOMINANT NEGATIVE FORM OF REV

MOLECULAR GENETIC INTERVENTION FOR AIDS--TRANSDOMINANT NEGATIVE FORM OF REV
艾滋病的分子遗传学干预--REV的跨显性阴性形式
批准号：
6113375
负责人：
Gary J Nabel
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113375
关键词：
AIDS therapy HIV infections blood treatment cell transplantation clinical research clinical trials gene therapy helper T lymphocyte human subject human therapy evaluation molecular genetics polymerase chain reaction

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中文摘要
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英文摘要
In this study, we will evaluate the efficacy of intracellular inhibition of HIV infection with a mutant form of Rev, Rev M10. We propose to determine whether Rev M10 can improve the survival of T cells in humans. We plan to accomplish this by introducing the Rev M10 gene into the CD4+ T cells of HIV infected patients, ex vivo. These cells will then be returned to the patient, and their survival measured by PCR.
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CORE--VECTOR CONSTRUCTION
CORE--QUANTITATIVE MOLECULAR ANALYSIS
COMBINATION GENE TRANSFER, ANTIVIRAL TREATMENT & IMMUNOSTIMULATION FOR HIV+
IMMUNOTHERAPY BY IN VIVO GENE TRANSFER INTO TUMORS
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