SPIN TAGGED ARTERIAL WATER PERFUSION MRI USING H2 150 BASED PERFUSION

使用基于 H2 150 的灌注进行旋转标记动脉水灌注 MRI

• 批准号: 6113317
• 负责人: ABASS none ALAVI
• 金额: $ 2.66万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6113317
• 关键词: blood flow measurement; brain imaging /visualization /scanning; cerebrovascular imaging /visualization; clinical research; diagnosis design /evaluation; diagnosis quality /standard; human subject; magnetic resonance imaging; perfusion; positron emission tomography

In contrast to Functional Magnetic Resonance Imaging (fMRI) methods that rely on the Blood Oxygenation Level Dependent (BOLD) effect to detect changes in brain perfusion, Spin Tagged Arterial Water Perfusion Magnetic Resonance Imaging (pMRI) yields quantitative data that in theory is directly comparable to perfusion imaging with Positron Emission Tomography (pPET). Unlike fully quantitated pPet, pMRI is non- invasive and does not use ionizing radiation. Nevertheless, pMRI has yet to be validated against an established perfusion imaging method like pPET. We propose a pilot study as a first step to validate pMRI in humans. Whole brain and regional cerebral blood flow (rCBF) measurements from the pMRI of normal volunteers will be compared against values from pPET, the current gold standard for in vivo measurement of brain perfusion. We aim to identify a correlation between these measurements, as well as, documents the intra and inter subject variation in the rCBF of normal subjects measured with pMRI. A quantitative description of these variations is necessary to document the reliabiity of the measurements and the range over which pMRI is valid.

与功能性磁共振成像（fMRI）方法相比， 依靠血氧水平依赖（BOLD）效应来检测 脑灌注变化，自旋标记动脉水灌注 磁共振成像（pMRI）产生定量数据， 该理论可直接与正电子灌注成像进行比较 发射断层扫描（pPET）。 与完全定量的pPet不同，pMRI是非定量的。 侵入性，不使用电离辐射。尽管如此，pMRI还没有 将针对已建立的灌注成像方法进行验证， pPET。 我们提出了一个试点研究作为第一步，以验证pMRI在人类。 全脑和局部脑血流量（rCBF）测量， 将正常志愿者的pMRI与来自pPET的值进行比较， 是目前体内脑灌注测量的金标准。 我们的目标是确定这些测量之间的相关性，以及， 记录了正常对照组rCBF的受试者内和受试者间变化 用pMRI测量的受试者。 对这些的定量描述 必须进行变更，以记录测量的可靠性 以及pMRI有效的范围。