FDG-PET Imaging in painful Hip Prosthesis

FDG-PET 成像在疼痛髋关节假体中的应用

• 批准号: 6932336
• 负责人: ABASS none ALAVI
• 金额: $ 51.96万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932336
• 关键词: bioimaging /biomedical imaging; blood glucose; clinical research; cost effectiveness; deoxyglucose; diagnosis design /evaluation; glucose metabolism; glucose transport; hip prosthesis; human subject; inflammation; longitudinal human study; pain; patient care management; positron emission tomography; postoperative state; prognosis

DESCRIPTION (provided by applicant): Approximately 200,000 total hip replacements are performed in the U.S. each year. Although the incidence of acute infection following hip replacement is reduced as certain preventative measures have been adopted, both early and late infections remain as significant sources of morbidity, mortality and substantial expenses. The treatment of infected joint replacements has been estimated to cost between $50,000-60,000 per patient. Establishing the diagnosis of infection is quite difficult, and much of the morbidity and cost encountered is due to the lack of a single test that is highly accurate, and cost effective in the management of patients with painful total hip prosthesis. Current diagnostic tests including routine radiography, laboratory studies, and nuclear medicine procedures, suffer from significant shortcomings including accuracy and cost. It has been shown that [ 18-F] fluorine deoxyglucose (FDG) and Positron Emission Tomography (PET) reveal sites of inflammation with high sensitivity and specificity. In a pilot study conducted at our institution, we have been able to demonstrate that FDG-PET imaging has high accuracy in the setting of painful total hip prosthesis in a relatively small patient population. The main objective of the proposed research study is to determine the efficacy of FDG-PET imaging in the management of a painful total hip prosthesis in a large patient population. We also intend to compare FDG-PET imaging directly to conventional techniques including radio labeled white cell imaging for the diagnosis of hip infection to determine whether FDG-PET imaging is superior to the existing techniques. Furthermore, we will optimize the FDG-PET imaging criteria for diagnosing infection associated with hip prosthesis. We plan to enroll 530 patients over 5 years for the purposes outlined in the application. By implementing the proposed research, we will be able to demonstrate the effectiveness of this technique in the management of patients with painful hip arthroplasty. We believe this promising technology has great potential for the accurate diagnosis of this serious and challenging clinical problem, and may substantially influence the outcome in these patients.

描述（由申请人提供）：美国每年约进行20万例全髋关节置换术。虽然髋关节置换术后急性感染的发生率降低了一定的预防措施，早期和晚期感染仍然是发病率，死亡率和大量费用的重要来源。据估计，治疗感染的关节置换术每名患者的费用在50 000至60 000美元之间。建立感染的诊断是相当困难的，并且所遇到的大部分发病率和成本是由于缺乏一种高度准确的单一测试，并且在疼痛的全髋关节假体患者的管理中具有成本效益。目前的诊断测试，包括常规射线照相术，实验室研究，和核医学程序，遭受显着的缺点，包括准确性和成本。已显示[ 18-F]氟脱氧葡萄糖（FDG）和正电子发射断层扫描（PET）以高灵敏度和特异性揭示炎症部位。在我们机构进行的一项试点研究中，我们已经能够证明FDG-PET成像在相对较小的患者群体中设置疼痛的全髋关节假体时具有很高的准确性。本研究的主要目的是确定FDG-PET成像在大患者人群中治疗疼痛性全髋关节假体的有效性。我们还打算直接比较FDG-PET成像与常规技术，包括用于诊断髋关节感染的放射性标记白色细胞成像，以确定FDG-PET成像是否上级现有技术。此外，我们将优化FDG-PET成像诊断髋关节假体相关感染的标准。我们计划在5年内招募530例患者，用于申请中概述的目的。通过实施拟议的研究，我们将能够证明这种技术在治疗髋关节置换术疼痛患者中的有效性。我们相信，这项有前途的技术在准确诊断这一严重且具有挑战性的临床问题方面具有巨大潜力，并可能对这些患者的结局产生重大影响。

项目成果

Emerging role of FDG-PET for optimal response assessment in infectious diseases and disorders.

FDG-PET 在传染病和病症最佳反应评估中的新兴作用。

• DOI: 10.1586/eri.10.167
• 发表时间: 2011
• 期刊: Expert review of anti-infective therapy
• 影响因子: 5.7
• 作者: Basu,Sandip;Alavi,Abass
• 通讯作者: Alavi,Abass

Critical role of 18F-labeled fluorodeoxyglucose PET in the management of patients with arthroplasty.

18F 标记的氟脱氧葡萄糖 PET 在关节置换术患者管理中的关键作用。

• DOI: 10.1016/j.rcl.2007.05.010
• 发表时间: 2007
• 期刊: Radiologic clinics of North America
• 影响因子: 1.9
• 作者: Zhuang,Hongming;Yang,Hua;Alavi,Abass
• 通讯作者: Alavi,Abass

FDG PET for diagnosing infection in hip and knee prostheses: prospective study in 221 prostheses and subgroup comparison with combined (111)In-labeled leukocyte/(99m)Tc-sulfur colloid bone marrow imaging in 88 prostheses.

• DOI: 10.1097/rlu.0000000000000464
• 发表时间: 2014-07
• 期刊: Clinical nuclear medicine
• 影响因子: 10.6
• 作者: Basu S;Kwee TC;Saboury B;Garino JP;Nelson CL;Zhuang H;Parsons M;Chen W;Kumar R;Salavati A;Werner TJ;Alavi A
• 通讯作者: Alavi A

Increased 18F-FDG uptake suggests synovial inflammatory reaction with osteoarthritis: preliminary in-vivo results in humans.

18F-FDG 摄取增加提示滑膜炎症反应与骨关节炎：人类体内的初步结果。

• DOI: 10.1097/mnm.0000000000000376
• 发表时间: 2015
• 期刊: Nuclear medicine communications
• 影响因子: 1.5
• 作者: Parsons,MollyA;Moghbel,Mateen;Saboury,Babak;Torigian,DrewA;Werner,ThomasJ;Rubello,Domenico;Basu,Sandip;Alavi,Abass
• 通讯作者: Alavi,Abass