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DMP 777 LUNG SPECIFIC ORAL ADMINISTRATION IN PATIENTS WITH CYSTIC FIBROSIS

DMP 777 LUNG SPECIFIC ORAL ADMINISTRATION IN PATIENTS WITH CYSTIC FIBROSIS
DMP 777 囊性纤维化患者的肺部特异性口服给药
批准号：
6263489
负责人：
DANIEL B ROSENBLUTH
金额：
$2.44万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6263489
关键词：
clinical research cystic fibrosis drug administration rate /duration drug screening /evaluation elastase inhibitor elastases enzyme activity extracellular human subject human therapy evaluation lung lavage metabolism disorder chemotherapy neutrophil oral administration pharmacokinetics

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中文摘要
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英文摘要
The primary objectives are to assess the magnitude of extacellular human neutrophil elastase (NE) ingibitory activity in bronchoalveolar lavage (BAL) fluid following 14 days of oral DMP 777 administration twice daily or three times daily in adult patients with cystic fibrosis (CF) and to correlate this effect with any observed changes in extracellualar HNE activity in BAL fluid with systmeic pharmacokinetic (PK) and pharmacodynamic (PD) data. Evaluate the safety of DMP 777. The secondary objective is to determine the correlation between the magnitude of BAL extracellular HNE inhibition and improvement in biological indices relevant to the pathogenesis of lung disease in CF.
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STANDARD VERSUS BIOFILM SUSCEPTIBILITY TESTING IN CYSTIC FIBROSIS
  • 批准号：
    7603356
  • 项目类别：
  • 资助金额：
    $0.14万
  • 财政年份：
    2007
  • 负责人：
    DANIEL B ROSENBLUTH
  • 依托单位：
    WASHINGTON UNIVERSITY
DMP 777 PHARMACOKINETICS AND PHARMACODYNAMICS IN CYSTIC FIBROSIS
  • 批准号：
    6263488
  • 项目类别：
  • 资助金额：
    $2.44万
  • 财政年份：
    1998
  • 负责人：
    DANIEL B ROSENBLUTH
  • 依托单位：
    WASHINGTON UNIVERSITY
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