MUTATIONS W/ SECONDARY LEUKEMIA FOR HODGKINS OR CHILDHOOD BRAIN TUMOR

霍奇金淋巴瘤或儿童脑肿瘤继发性白血病突变

• 批准号: 6263400
• 负责人: EDWARD C HALPERIN
• 金额: $ 4.09万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263400
• 关键词: Hodgkin's disease; acute myelogenous leukemia; brain neoplasms; cancer complication; chromosome aberrations; clinical research; disease /disorder etiology; gene mutation; human subject; iatrogenic disease; lymphocyte; neoplasm /cancer genetics; neoplasm /cancer radiation therapy; pediatric neoplasm /cancer; radiation genetics

In this protocol, we seek to determine the frequency of chromosome aberrations in peripheral blood lymphocytes specifically associated with iatrogenic acute myelogenous leukemia using chromosome painting techniques following radiotherapy and/or chemotherapy used in the treatment of Hodgkin's disease and childhood brain tumors. We are also using blood samples from these patients to study toxicological response to carcinogen, exposure and gene rearrangements associated with deregulation of a growth promoting oncogene. Through these techniques, we hope to develop predictive assays for treatment-induced second malignant neoplasms which may lead to an improved understanding of this complication of cancer treatment and, perhaps, preventive and therapeutic strategies.

在该协议中，我们试图确定外周血淋巴细胞中染色体畸变的频率，该细胞特异性与医源性急性急性髓质性白血病使用放射疗法和/或化学疗法后使用，用于治疗霍德吉金氏病和儿童脑肿瘤。我们还使用这些患者的血液样本来研究对致癌物，暴露和基因重排的毒理学反应，与促进癌基因的消失有关。通过这些技术，我们希望为治疗引起的第二次恶性肿瘤开发预测性测定，这可能会提高人们对癌症治疗并发症以及预防和治疗策略的这种并发症的了解。