CRL 5861 (PURIFIED POLOXAMER 188) IN SICKLE CELL DISEASE & VASO OCCLUSIVE CRISIS

镰状细胞病是人类最常见的遗传性血液病。这种疾病的临床表现和严重程度各不相同。患有这种衰弱疾病的人经常受到需要住院的急性疼痛危机的困扰，以及对各种器官系统的攻击，导致这些器官的损害和/或衰竭。这项研究的重点是痛苦的危机。危机平均持续约7-10天。在自然病史研究(CSSCD-SCD合作研究)的结果中，Platt等人证明，大约三分之一的SCD患者在镰状细胞危象中死亡，通常死于与此事件相关的并发症，如中风、癫痫或急性胸部综合征。这项研究的目的是评估FLOCOR与安慰剂对照在缩短SCD患者血管闭塞危象持续时间方面的疗效。

Sickle Cell Disease (SCD) is the most common human hereditary hematologic disorder. This disease varies in its clinical manifestation and severity. Persons with this debilitating disease are often plagued with acute pain crises requiring hospitalization as well as assaults on various organ systems leading to impairment and/or failure of those organs. This study focuses on the painful crisis. The average crisis lasts for approximately 7-10 days. In results from the natural history study (CSSCD-Cooperative Study of SCD), Platt et al documented that approximately one-third of SCD patients die during a sickle cell crisis, usually after complications associated with this event, i.e. stroke, seizure or acute chest syndrome. The purpose of this study is to assess the efficacy of FLOCOR compared to placebo control in reducing the duration of vaso-occlusive crisis in patients with SCD.