CPC111 IN SICLKE CELL CRISIS--STAGES 1, 2, & 3

这项研究的目的是提供一种干预措施， 缩短这场痛苦的危机的持续时间。1，6-二磷酸果糖 (FDP)是一种天然存在于人体内的磷酸化糖 尸体。其无氧代谢通过糖酵解的方式进行，并产生 4摩尔/摩尔FDP，其产率是葡萄糖的两倍。如果FDP可以 帮助红细胞抵抗刺激，形成镰刀状，通过 增加细胞内三磷酸腺苷的利用率，然后给药 自民党在危机早期可能会缩短其持续时间。四到八个科目 将进入第二/第三阶段。在第二阶段/第三阶段给出了主题 一次输液超过30分钟，q6小时超过72小时。第三阶段是 开放标签输液，每6小时1次，连服1-7天。持续时间 3期的病情会因患者而异。 到目前为止，我们已经招募了7名患者。我们最近接到通知， 赞助公司已在达到预期目标后关闭注册 来自不同中心的研究对象数量，因此我们将 不会再招募更多的病人参加这个治疗方案。

The purpose of this study is to provide an intervention that will help shorten the duration of the painful crisis. Fructose-1,6-diphosphate (FDP) is a phosphorylated sugar that is present naturally in the human body. Its anaerobic metabolism proceeds by way of glycolysis and yields 4 mol ATP per mol of FDP which is twice the yield of glucose. If FDP can help the red cell resist the stimulus to form the sickle shape, by increasing the intracellular availability of ATP, then administration of FDP early in a crisis could shorten its duration. Four to eight subjects will be entered in stage two/three. In stage two/three subjects are given one infusion over thirty minutes q 6 hours over 72 hours. Stage three is an open label infusion q 6 hours for an additional 1-7 days. The duration of Stage 3 will vary from patient to patient. To date, we have enrolled 7 patients. We were recently notified that the sponsoring company has closed enrollment after reaching their desired number of study subjects from among the various centers, therefore we will not be enrolling any more patients on this protocol.