CPC111 IN SICLKE CELL CRISIS--STAGES 1, 2, & 3
CPC111 IN SICLKE CELL CRISIS--STAGES 1, 2, & 3
批准号:
6274104
负责人:
BRIAN K ADLER
金额:
$2.59万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-01-26 至 1998-11-30
中文摘要
本研究的目的是提供一种有帮助的干预方法
英文摘要
The purpose of this study is to provide an intervention that will help
shorten the duration of the painful crisis. Fructose-1,6-diphosphate
(FDP) is a phosphorylated sugar that is present naturally in the human
body. Its anaerobic metabolism proceeds by way of glycolysis and yields
4 mol ATP per mol of FDP which is twice the yield of glucose. If FDP can
help the red cell resist the stimulus to form the sickle shape, by
increasing the intracellular availability of ATP, then administration of
FDP early in a crisis could shorten its duration. Four to eight subjects
will be entered in stage two/three. In stage two/three subjects are given
one infusion over thirty minutes q 6 hours over 72 hours. Stage three is
an open label infusion q 6 hours for an additional 1-7 days. The duration
of Stage 3 will vary from patient to patient.
To date, we have enrolled 7 patients. We were recently notified that the
sponsoring company has closed enrollment after reaching their desired
number of study subjects from among the various centers, therefore we will
not be enrolling any more patients on this protocol.
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CRL 5861 (PURIFIED POLOXAMER 188) IN SICKLE CELL DISEASE & VASO OCCLUSIVE CRISIS
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批准号:6565382
-
项目类别:
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资助金额:$17.53万
-
财政年份:2001
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负责人:BRIAN K ADLER
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依托单位:
CRL 5861 (PURIFIED POLOXAMER 188) IN SICKLE CELL DISEASE & VASO OCCLUSIVE CRISIS
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批准号:6410698
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项目类别:
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资助金额:$17.53万
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财政年份:2000
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负责人:BRIAN K ADLER
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依托单位:
CRL 5861 (PURIFIED POLOXAMER 188) IN SICKLE CELL DISEASE & VASO OCCLUSIVE CRISIS
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批准号:6302992
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项目类别:
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资助金额:$2.95万
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财政年份:1999
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负责人:BRIAN K ADLER
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依托单位:
CRL 5861 (PURIFIED POLOXAMER 188) IN SICKLE CELL DISEASE & VASO OCCLUSIVE CRISIS
-
批准号:6263443
-
项目类别:
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资助金额:$2.95万
-
财政年份:1998
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负责人:BRIAN K ADLER
-
依托单位:
DEVELOPMENTAL REGULATION AND PROCESSING OF RIBOSOMAL RNA
-
批准号:2458091
-
项目类别:
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资助金额:$8.96万
-
财政年份:1993
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负责人:BRIAN K ADLER
-
依托单位:
DEVELOPMENTAL REGULATION AND PROCESSING OF RIBOSOMAL RNA
-
批准号:2100799
-
项目类别:
-
资助金额:$7.88万
-
财政年份:1993
-
负责人:BRIAN K ADLER
-
依托单位:
DEVELOPMENTAL REGULATION AND PROCESSING OF RIBOSOMAL RNA
-
批准号:2100801
-
项目类别:
-
资助金额:$8.9万
-
财政年份:1993
-
负责人:BRIAN K ADLER
-
依托单位:
DEVELOPMENTAL REGULATION AND PROCESSING OF RIBOSOMAL RNA
-
批准号:2100800
-
项目类别:
-
资助金额:$8.96万
-
财政年份:1993
-
负责人:BRIAN K ADLER
-
依托单位:
DEVELOPMENTAL REGULATION AND PROCESSING OF RIBOSOMAL RNA
-
批准号:3086002
-
项目类别:
-
资助金额:$7.88万
-
财政年份:1993
-
负责人:BRIAN K ADLER
-
依托单位:
CPC111 IN SICLKE CELL CRISIS--STAGES 1, 2, & 3
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批准号:6112870
-
项目类别:
-
资助金额:$3.06万
-
财政年份:--
-
负责人:BRIAN K ADLER
-
依托单位: