CoV-Ind-UK: Prospective investigation of the determinants for COVID-19 outcomes amongst South Asians in India and the United Kingdom.

CoV-Ind-UK：对印度和英国南亚人中 COVID-19 结果的决定因素进行前瞻性调查。

• 批准号: MR/V040049/1
• 负责人: John Chambers
• 金额: $ 123.52万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV040049%2F1
• 关键词: CoV; Ind; UK; Prospective; investigation

Results of studies from India and the UK show that South Asian people are at high risk for risk COVID-19, or to being infected with the SARS-CoV2 virus which causes this illness. The reasons for this increased risk in South Asians are not known. To address this important knowledge gap, we will take advantage of our established 'population cohorts' comprising South Asian men and women in India and the UK who have been under surveillance for up to 20 years. All participants were recruited before the onset of the COVID-19 pandemic, and have measures of key risk factors relevant to COVID-19, including weight, blood pressure, diabetes, heart disease and socio-economic factors. In addition, we have comprehensive assessment of metabolism, genetic variation, and of gene regulation for many of the participants, generated in previous research projects. These already available cohorts, with rich data and samples, provide a powerful and efficient opportunity to define the primary risk factors for COVID-19 in South Asians. In this new study, we will invite 30,000 of these South Asian people (10,000 in India, 20,000 in the UK) to be tested for evidence of infection with the SARS-CoV2 virus (antibody test). We will also ask them to complete a questionnaire about COVID-19 symptoms, relevant behaviours disease, attitudes to vaccination, and impact of the COVID-19 pandemic (and control measures) on mental, physical and financial wellbeing. We will link to medical records and mortality data where possible to identify people with severe COVID-19. We will use the data collected to determine what are the major risk factors in South Asians in India and the UK, for infection with SARS-CoV2, or experiencing severe or prolonged COVID-19. We will focus initially on recognised risk factors such as adiposity, raised blood pressure and diabetes, cardiovascular disease, health behaviours (alcohol, smoking, physical inactivity), socio-economic indicators, and measures of metabolic health. We will compare our results in South Asians with equivalent measures for Europeans, and determine whether known risk factors explain the high risk of COVID-19 in Asians. We will use the results to develop simple tools for predicting risk of COVID-19 in South Asians, that can be used to prioritise people for vaccination or behavioural interventions, and to protect them from COVID-19. We will also report on vaccine hesitancy in South Asians (delayed or low acceptance of vaccination) as well as the main reasons for this. This will help identify potential obstacles to successful immunisation programmes and the need for public health education to build understanding, trust and confidence. Finally, we will use 'all-of-the-data' including the available health and genetic data to investigate for previously unidentified risk factors or biological processes that might contribute to COVID-19 in South Asians. The findings will provide much needed knowledge into the reasons underlying the high burden of COVID-19 in South Asians, and will inform health policy and practice for prevention and control of the disease in India, the UK and globally. We will deliver significant initial outputs within the first 3 months, thus bringing early impact from the work. The research is led by teams from India and the UK who have been at the forefront of responses to COVID-19 at national level. The team also have established expertise, and track record in research to understand the health of South Asian populations. Our research thus addresses a major public health challenge, is timely, efficient and has a high probability of delivering results that will reduce morbidity and mortality from COVID-19 amongst South Asians, who represent 25% of the world's population.

来自印度和英国的研究结果表明，南亚人感染COVID-19或感染导致这种疾病的SARS-CoV 2病毒的风险很高。南亚人风险增加的原因尚不清楚。为了解决这一重要的知识差距，我们将利用我们已建立的“人口队列”，包括印度和英国的南亚男性和女性，他们已被监视长达20年。所有参与者均于COVID-19大流行爆发前招募，并已测量与COVID-19相关的关键风险因素，包括体重、血压、糖尿病、心脏病及社会经济因素。此外，我们对许多参与者的代谢，遗传变异和基因调控进行了全面评估，这些都是在以前的研究项目中产生的。这些已经可用的队列具有丰富的数据和样本，为确定南亚人COVID-19的主要风险因素提供了强大而有效的机会。在这项新的研究中，我们将邀请3万名南亚人（印度1万人，英国2万人）进行SARS-CoV 2病毒感染证据检测（抗体检测）。我们亦会要求他们填写有关COVID-19症状、相关行为疾病、对疫苗接种的态度，以及COVID-19大流行（及控制措施）对精神、身体及财务健康的影响的问卷。我们将在可能的情况下链接医疗记录和死亡率数据，以识别患有严重COVID-19的人。我们将使用收集到的数据来确定印度和英国南亚人感染SARS-CoV 2或经历严重或长期COVID-19的主要风险因素。我们将首先关注公认的风险因素，如肥胖，血压升高和糖尿病，心血管疾病，健康行为（酒精，吸烟，缺乏身体活动），社会经济指标和代谢健康的措施。我们将比较我们在南亚人中的结果与欧洲人的等效措施，并确定已知的风险因素是否可以解释亚洲人患COVID-19的高风险。我们将利用研究结果开发简单的工具，用于预测南亚人感染COVID-19的风险，可用于优先接种疫苗或行为干预，并保护他们免受COVID-19的影响。我们还将报告南亚人的疫苗犹豫（延迟或低接受疫苗接种）及其主要原因。这将有助于确定成功的免疫接种计划的潜在障碍，以及公共卫生教育的必要性，以建立理解，信任和信心。最后，我们将使用“所有数据”，包括可用的健康和遗传数据，以调查可能导致南亚人COVID-19的先前未识别的风险因素或生物过程。这些发现将为南亚人COVID-19高负担的原因提供急需的知识，并将为印度、英国和全球预防和控制该疾病的卫生政策和实践提供信息。我们将在头3个月内提供重要的初步产出，从而使工作产生早期影响。该研究由来自印度和英国的团队领导，他们一直处于国家层面应对COVID-19的最前沿。该团队还建立了专业知识和研究记录，以了解南亚人口的健康状况。因此，我们的研究解决了一个重大的公共卫生挑战，是及时的，有效的，并有很大的可能性提供的结果，将减少南亚人，谁占世界人口的25%的COVID-19的发病率和死亡率。