HDHL MICA: Microbiota-Inflammation-Brain axis in heart failure ... (AMBROSIA)

HDHL MICA：心力衰竭中的微生物群-炎症-脑轴......（AMBROSIA）

• 批准号: MR/V039865/1
• 负责人: Iain Andrew Brownlee
• 金额: $ 33.96万
• 依托单位: Northumbria University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV039865%2F1
• 关键词: HDHL; MICA; Microbiota; Inflammation; Brain

Long-term limited dietary intake (undernutrition) in older adults can greatly increase the risk of ill-health and increase frailty. Undernutrition is a common issue in patients diagnosed with heart failure and atrial fibrillation (an issue which causes an irregular heartbeat). Improving dietary intake in this patient group could improve physical functionality and should also reduce risk of future heart issues. The aim of this EU collaboration (the AMBROSIA project) is to test whether dietary counselling and provision of a novel fortified food product can benefit this patient group. This collaboration researchers across four different countries (Italy, Republic of Ireland, Spain and the UK) and bring together industrial and academic expertise.The first goal of this study will be to design the novel food product (the AMBROSIA bar), specifically enriched an ideal mix of protein, fibre and other factors. The impacts of dietary counselling, either alone or in tandem with AMBROSIA bar intake will be assessed in 120 heart failure and atrial fibrillation patients. Blood samples, dietary data, cognitive testing and measurements of body composition will be collected from patients to track the impact of these two treatments. Additional analysis of blood, urine and stool samples will also analyse wider changes in metabolites and gut microbiota that will support understanding of the relationship of these factors with disease management. Use of cutting-edge machine-learning approaches will also help to uncover new "signatures" of dietary intake, frailty and health status. Such findings would have wider benefit on the understanding of the impact of dietary intake on supporting positive ageing

老年人长期有限的饮食摄入（营养不足）会大大增加健康不良的风险，并增加虚弱。营养不良是诊断为心力衰竭和房颤（导致心跳不规则的问题）的患者的常见问题。改善这一患者群体的饮食摄入量可以改善身体功能，也应该降低未来心脏问题的风险。这项欧盟合作（AMBROSIA项目）的目的是测试饮食咨询和提供一种新型强化食品是否能使这一患者群体受益。这项合作的研究人员来自四个不同的国家（意大利，爱尔兰共和国，西班牙和英国），并汇集了工业和学术专业知识。这项研究的第一个目标将是设计新的食品（AMBROSIA酒吧），特别是丰富了蛋白质，纤维和其他因素的理想组合。将在120例心力衰竭和房颤患者中评估饮食咨询（单独或与氨溴索棒摄入联合）的影响。将收集患者的血液样本、饮食数据、认知测试和身体成分测量，以跟踪这两种治疗的影响。对血液、尿液和粪便样本的额外分析还将分析代谢物和肠道微生物群的更广泛变化，这将有助于理解这些因素与疾病管理的关系。使用尖端的机器学习方法也将有助于发现饮食摄入、虚弱和健康状况的新“特征”。这些发现将有助于更广泛地了解饮食摄入对支持积极老龄化的影响

项目成果

The Diet of Children Attending a Holiday Programme in the UK: Adherence to UK Food-Based Dietary Guidelines and School Food Standards.

• DOI: 10.3390/ijerph19010055
• 发表时间: 2021-12-22
• 期刊: International journal of environmental research and public health
• 作者: Crilley E;Brownlee I;Defeyter MA
• 通讯作者: Defeyter MA

A Pilot Pre and Post 4 Week Intervention Evaluating the Effect of a Proprietary, Powdered, Plant Based Food on Micronutrient Status, Dietary Intake, and Markers of Health in a Healthy Adult Population.

• DOI: 10.3389/fnut.2022.945622
• 发表时间: 2022
• 期刊: FRONTIERS IN NUTRITION
• 影响因子: 5
• 作者: Wilcox, Matthew D.;Chater, Peter I.;Stanforth, Kyle J.;Williams, Rebecca;Brownlee, Iain A.;Pearson, Jeffrey P.
• 通讯作者: Pearson, Jeffrey P.

The Nutritional Quality of Food Provision at UK Government-Funded Holiday Clubs: A Cross-Sectional Analysis of Energy and Nutrient Content.

• DOI: 10.3390/nu15081937
• 发表时间: 2023-04-18
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Vitale M;Crossland S;Shinwell J;Stretesky PB;Defeyter MA;Brownlee IA
• 通讯作者: Brownlee IA