EFFECT OF INSULIN RESISTANCE ON THE LIPOPROTEIN RESPONSE TO EGG FEEDING

胰岛素抵抗对脂蛋白对鸡蛋喂养反应的影响

• 批准号: 6113111
• 负责人: ROBERT Henry KNOPP
• 金额: $ 0.39万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113111
• 关键词: blood lipoprotein; body composition; cholesterol; clinical research; clinical trials; dietary lipid; eating; egg food product; glucose tolerance test; high density lipoproteins; human subject; insulin sensitivity /resistance; low density lipoprotein; nutrition related tag; obesity

To determine if insulin resistance or obesity is associated with plasma lipid response to egg consumption, 201 subjects will be divided into three equal groups, lean insulin sensitive, lean insulin resistant, and obese insulin resistant, using an insulin sensitivity index < or > 7.0 determined by a frequently sampled IV glucose tolerance test and BMI > or < 27.5 kg/m2. Subjects will be recruited from institutional personnel and public advertising, taught the NCEP Step I (moderately low fat) diet and fed in a double-blind cross-over design pasteurized whole egg and/or egg substitute in three randomized monthly protocols at levels of 0, 2 or 4 eggs daily, separated by one month washout periods. The effect of egg feeding will be assessed by changes in LDL-cholesterol, and also by changes in HDL-cholesterol, apoprotein B and density gradient vertical analytical profiles of the lipoprotein pattern.

为了确定胰岛素抵抗或肥胖是否与对鸡蛋消耗的血浆脂质反应相关，将201名受试者分成三个相等的组，瘦胰岛素敏感性、瘦胰岛素抵抗和肥胖胰岛素抵抗，使用< or >通过频繁采样的IV葡萄糖耐量试验确定的胰岛素敏感性指数7.0和BMI &gt;或&lt; 27.5 kg/m2。受试者将从机构人员和公共广告中招募，教授NCEP步骤I（中等低脂肪）饮食，并在三个随机的每月方案中以双盲交叉设计巴氏灭菌的全蛋和/或鸡蛋替代品喂养，每天0、2或4个鸡蛋的水平，间隔一个月的洗脱期。 将通过LDL-胆固醇的变化以及HDL-胆固醇、载脂蛋白B和脂蛋白模式的密度梯度垂直分析曲线的变化来评估鸡蛋喂养的影响。