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OPTIMUM (Oxidative Flow Platform Utilising Porous liquids, 3D printing and Microbubble Technology at Almac)

OPTIMUM（Almac 利用多孔液体、3D 打印和微泡技术的氧化流平台）

基本信息

批准号：
MR/W001764/1
负责人：
Megan Rebecca Smyth
金额：
$ 95.52万
依托单位：
Almac Sciences Ltd
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FW001764%2F1
关键词：
OPTIMUM Oxidative Flow Platform Utilising

项目摘要

OPTIMUM is an innovative and novel project, centred on the development of a female Future Leader in the industrial chemical sector, but which will also deliver a successful continuous oxidation platform utilising molecular oxygen. Molecular oxygen is a cheap, abundant, atom efficient reagent but is currently under utilised within the chemical manufacturing industry. Economy of scale allows bulk chemical processes to be performed in a highly integrated manner, with attendant operational efficiencies and synergies. For CDMOs like ASL operating within the pharmaceutical/fine chemical industry this is simply not feasible, due to the lower delivery targets/more complex molecules required, and as such flow processes (like their batch counterparts) need to be developed within multi-purpose reactors. Aerobic oxidations fall into a unique category of reactions which are difficult to perform in batch, due to the considerable headspace within reactors and the associated risk of explosion.There are five strategic drivers towards choosing flow chemistry over traditional batch as outlined in points A to E:A. Faster reactions: typically under continuous flow reactions are faster due to improved mixing, better heat transfer as a result of the smaller-scale architectures offering higher surface area to volume when compared with traditional batch vessels. Reaction rate is increased also by the ability to access temperatures and pressures inaccessible in batch and there is the potential for automated reaction screening.B. Safer reactions: continuous flow is inherently safer due to the small volumes reacting at any one time with reactive intermediates/hazardous reagents handled in situ thus minimising the risk significantly.C. Challenging reactions: reactions which are difficult to scale up in batch, such as high pressure, high energy, oxidation or photochemical can be performed under continuous flow.D. Product quality: tight controls of stoichiometry improves product quality, as product is pumped away from reagents resulting in fewer impurities formed as by-products. In-line monitoring can identify a change in product quality and allow for diversion to waste eliminating failed batches. The ability to perform a controlled quench means simple work-up with typically a reduced number of handling steps required.E. Smaller footprint: equipment is much smaller than typical batch vessels with the ability to tailor the flow rig to suit the process and higher unit productivity.The public may well be surprised at the unsophisticated methods that are employed for chemical and pharmaceutical production and the large amounts of environmentally harmful waste generated in the production of medicines and fine chemicals that we all rely on. The UK chemical industry faces serious competition from low cost economies and real difficulties in bringing new products to the market. To survive as a significant part of the UK economy, and continue providing healthcare solutions, the industry seeks to remain competitive through using cutting-edge technologies and more efficient operating practices, all with a backdrop of ensuring sustainability in its practices. Although continuous flow has gained increasing attention in recent years, the current-state-of-the-art for industrial chemical production is still simple batch processes. OPTIMUM aims to further train/develop the identified Fellow (along with their associated project team) and carry out research in areas which will help change the current state-of-the-art production processes developing continuous flow equipment trains for the production of fine chemicals.

OPTIMUM是一个创新和新颖的项目，专注于工业化学领域女性未来领导者的发展，但也将提供一个成功的利用分子氧的连续氧化平台。分子氧是一种廉价、丰富、原子效率高的试剂，但目前在化学制造业中的利用率较低。规模经济允许以高度集成的方式进行批量化学工艺，同时具有相应的运营效率和协同效应。对于在制药/精细化学工业中操作的CDMO（如ASL），这是根本不可行的，因为所需的递送靶点较低/分子更复杂，因此需要在多用途反应器中开发流动过程（如其批处理对应物）。好氧氧化属于一种独特的反应类型，由于反应器内相当大的顶部空间和相关的爆炸风险，难以批量进行。选择流动化学而非传统批量有五个战略驱动因素，如A至E点所述：A.更快的反应：通常在连续流动下，由于改进的混合、更好的传热，反应更快，这是由于与传统的间歇容器相比，较小规模的结构提供了更高的表面积与体积比。反应速率也增加的能力，以访问温度和压力无法在批量和有潜力的自动化反应筛选。B.更安全的反应：连续流动本质上是更安全的，因为在任何一个时间与原位处理的活性中间体/危险试剂反应的体积小，从而显著地最小化风险。反应：难以批量放大的反应，如高压、高能、氧化或光化学反应可以在连续流下进行。产品质量：化学计量的严格控制提高了产品质量，因为产品从试剂中泵出，导致较少的杂质作为副产物形成。在线监测可以识别产品质量的变化，并允许转移到废物，消除不合格批次。进行受控淬火的能力意味着简单的后处理，通常需要减少的处理步骤。占地面积更小：英国化学工业的设备比典型的间歇式容器小得多，能够根据工艺要求定制流动装置，单位生产率更高。公众可能会对化学和制药生产所采用的简单方法以及我们所依赖的药品和精细化学品生产中产生的大量有害环境的废物感到惊讶。英国化学工业面临着来自低成本经济和将新产品推向市场的真实的困难。为了作为英国经济的重要组成部分生存下来，并继续提供医疗保健解决方案，该行业寻求通过使用尖端技术和更有效的运营实践来保持竞争力，所有这些都是在确保其实践可持续性的背景下进行的。虽然连续流动近年来受到越来越多的关注，但目前工业化学生产的最新技术仍然是简单的间歇过程。OPTIMUM旨在进一步培训/发展确定的研究员（沿着他们的相关项目团队），并在有助于改变当前最先进的生产工艺的领域开展研究，开发用于精细化学品生产的连续流设备系列。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Modular Synthesis of Benzoylpyridines Exploiting a Reductive Arylation Strategy

DOI：
10.1021/acs.orglett.3c03833
发表时间：
2023-12-22
期刊：
ORGANIC LETTERS
影响因子：
5.2
作者：
Alfano，Antonella Ilenia;Smyth，Megan;Baumann，Marcus
通讯作者：
Baumann，Marcus

Continuous-flow transfer hydrogenation of benzonitrile using formate as a safe and sustainable source of hydrogen

DOI：
10.1039/d3re00195d
发表时间：
2023
期刊：
Reaction Chemistry & Engineering
影响因子：
0
作者：
Seán D Dempsey;Ailbhe A Ryan;Megan Smyth;T. Moody;S. Wharry;Karen Fahey;A. Beale;Sofia Mediavilla Madrigal;Paul Dingwall;David W. Rooney;P. Knipe;M. Muldoon;Jillian M. Thompson
通讯作者：
Seán D Dempsey;Ailbhe A Ryan;Megan Smyth;T. Moody;S. Wharry;Karen Fahey;A. Beale;Sofia Mediavilla Madrigal;Paul Dingwall;David W. Rooney;P. Knipe;M. Muldoon;Jillian M. Thompson

Continuous-Flow Synthesis of Cyclobutenes Using LED Technology