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GENETIC CAUSES OF LIMB MALFORMATIONS

GENETIC CAUSES OF LIMB MALFORMATIONS
四肢畸形的遗传原因
批准号：
6113506
负责人：
JEFFREY W INNIS
金额：
$2.14万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6113506
关键词：
Epstein Barr virus cell line clinical research congenital skeletal disorder gene expression genetic mapping human genetic material tag human subject limbs lymphoblast tissue /cell culture

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中文摘要
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英文摘要
The overall aim of this project is to identify the gene or genes responsible for limb malformations in humans. The Human Genetic Studies Core and Cell immortalization Laboratory of the CRC would be utilized for the production of immortalized cell lines from subjects as they are identified. The availability of lymphoblast cells will facilitate delineation of the specific genetic defect. Lymphocytes will be immortalized with EBV to provide a renewable supply of cells and DNA for analysis.
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Genetic Mechanisms of Vertebrate Caudal Limb Field
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