AROUSAL THRESHOLD TO AUDITORY STIMULATION DURING SLEEP IN CHILDREN

阻塞性睡眠呼吸暂停综合征（OSAS）是儿童发病的常见原因。在气道阻塞时从睡眠中唤醒被认为是一种保护性反射，可以重建气道通畅，防止严重的、危及生命的窒息。然而，与成人相比，儿童通常没有与呼吸暂停相关的皮层觉醒。目前尚不清楚儿童缺乏唤醒是由于唤醒机制的普遍缺陷还是由于更具体的缺陷。我们之前的研究表明，OSAS患儿对高碳酸血症和吸气阻力负荷的唤醒反应受损。然而，这可能是继发于OSAS。本研究的目的是通过评估对声刺激的唤醒反应来分析整体唤醒阈值是否异常。到目前为止，我们已经评估了5名OSAS患者和2名对照患者的声唤起。在分析数据之前，还需要研究更多的主题。

The obstructive sleep apnea syndrome (OSAS) is a common cause of morbidity in childhood. Arousal from sleep during airway obstruction has been regarded as a protective reflex that reestablishes airway patency and prevents severe, life-threatening asphyxia. However, children, in contrast to adults, often do not have cortical arousals in association with apneas. It is still not clear whether this lack of arousal in children is due to a general defect in arousal mechanism or to more specific defects. We have previously shown that children with OSAS have impaired arousal responses to hypercapnia and inspiratory resistance loading. However, this may have developed secondary to OSAS. The objective of this study is to analyze whether the overall arousal threshold is abnormal, by evaluating the arousal response to an acoustic stimulus. To date, we have evaluated acoustic arousal in five subjects with OSAS and two controls. Further subjects need to be studied before the data can be analyzed.