GENETIC STUDIES OF OBSESSIVE COMPULSIVE DISORDER--BLOOD COLLECTION PHASE

我们正在确定多个一级亲属的家庭， 强迫症的诊断 这些家庭 从任何来源确定，包括约翰霍普金斯的转诊 临床医生和私人治疗师。 研究对象为 接受精神科医生和临床心理学家的检查。 目的是 对所有家庭成员进行临床评估， 每个人的样品。 用于未来DNA提取的细胞系正在 开发 迄今为止，我们已对15名受试者中的31名进行了临床检查 以这种方式确定的家庭，并获得血液样本， 他们 一旦采访了足够数量的受试者， 采集血样后，我们将准备进行基因研究 这些家庭，包括联系和协会的战略。 最终的目标是确定参与发展的基因， 紊乱 这将阐明强迫症的病理生理学，并导致 更合理的治疗。

We are identifying families in which multiple first-degree members have a diagnosis of obsessive-compulsive disorder (OCD). These families are being identified from any source, including referrals from Johns Hopkins clinicians and private therapists in the community. The subjects are being examined by psychiatrists and clinical psychologists. The aim is to clinically evaluate all the family members and to obtain a blood sample from each. Cell lines for future DNA extraction are being developed. To date, we have clinically examined 31 subjects in 15 families identified in this manner, and obtained blood samples from them. Once an adequate number of subjects has been interviewed and blood samples collected, we will be poised to proceed to genetic studies of these families, including both linkage and association strategies. The ultimate goal is to identify gene(s) involved in the development of the disorder. This will clarify the pathophysiology of OCD and lead to more rational treatments.