GENETIC STUDIES OF OCD--BLOOD COLLECTION PHASE

我们正在进行一项关于强迫症的大型家庭研究 (强迫症)，对100名强迫症先证者进行彻底的精神检查 和他们的一级亲属，以及100名对照先证者和他们的 一级亲属。这项研究的具体目的是确定 如果强迫症、强迫行为、抽动障碍和 其他精神疾病在强迫症的亲属中更高。 先证者；比较家族性和零星(非家族性)强迫症先证者 关于临床特征；澄清表型谱 可以在强迫症家庭中翻译的条件；并使用 分离分析探讨强迫症的遗传方式。 先证者是从五个治疗地点随机挑选出来的。 在年龄、性别和种族方面与强迫症病例相匹配的控制措施正在进行 通过随机数字拨号获得。 我们预计研究结果将表明强迫症是 家族性的，我们假设这种情况有潜在的 遗传基础。因此，我们正在向议员采集血液样本 强迫症家族，提取DNA和冷冻淋巴细胞，用 未来进行基因研究的目的。迄今为止，我们 已经确定了76个强迫症家庭和48个对照家庭 参与研究的共有179名受试者 检查过了。已从94名强迫症成员身上采集了血液样本 并储存在两个参与实验室中。 我们计划继续执行议定书，以便将总共100名强迫症患者包括在内 先证者及其一级亲属。然后我们将做好准备 无论是系统的全基因组搜索还是候选基因方法 确定这种繁重的神经精神疾病的遗传基础 条件。

We are conducting a large family study of obsessive-compulsive disorder (OCD), conducting thorough psychiatric examinations of 100 OCD probands and their first degree relatives, and 100 control probands and their first-degree relatives. The specific aims of the study are to determine if the rates of OCD, obsessive-compulsive behaviors, tic disorders, and other psychiatric conditions are higher in the relatives of the OCD probands; to compare familial and sporadic (non-familial) OCD probands with respect to clinical features; to clarify the phenotypic spectrum of conditions that may be translated in the OCD families; and to use segregation analysis to investigate the mode of inheritance of OCD. Probands are being randomly selected from five treatment sites. Controls, matched to the OCD cases on age, sex, and race, are being obtained by random digit dialing. We anticipate that the results of the study will indicate that OCD is familial, and we hypothesize that the condition has an underlying genetic basis. Therefore, we are collecting blood samples from members of the OCD families, and extracting DNA and freezing lymphocytes, with the purpose of conducting genetic studies in the future. To date, we have identified 76 OCD and 48 control families who have agreed to participate in the study, and a total of 179 subjects have been examined. Blood samples have been collected from 94 members of the OCD families and are stored in two participating laboratories. We plan to proceed with the protocol so as to include a total of 100 OCD probands and their first-degree relatives. We then will be poised for either a systematic genome-wide search or candidate gene approach to identify the genetic basis of this burdensome neuropsychiatric condition.