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ACTG 285 STEM CELL MOBILIZATION AND HARVESTING WITH FILGRASTIM

ACTG 285 STEM CELL MOBILIZATION AND HARVESTING WITH FILGRASTIM
使用 FILGRASTIM 动员和收获 ACTG 285 干细胞
批准号：
6114147
负责人：
Robert Turner Schooley
金额：
$3.22万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6114147
关键词：
cell motility clinical research colony stimulating factor hematopoietic stem cells human subject recombinant proteins

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中文摘要
翻译
ACTG 285-一项使用非格列汀动员和采集外周血中干细胞的初步研究。这项研究探索了不同HIV-1感染阶段的人和HIV-1血清阴性的人，Filgrtimm动员CD34+干细胞进入外周血的能力是否有显著差异。这项研究的目的是确定干细胞采集的安全性，并确定在HIV-1感染的不同阶段的受试者服用非格列西姆后，新鲜采集的和冷冻保存的干细胞被动员到外周血中的表面表型和功能特征。这项试验的结果尚未公布。
英文摘要
ACTG 285 - A Pilot Study of Stem Cell Mobilization and Harvesting from the Peripheral Blood Using Filgrastim. The study explored whether the ability of Filgrastim to mobilize CD34+ stem cells into the peripheral blood differs markedly among individuals with various stages of HIV-1 infection and HIV-1 seronegative individuals. The study's objectives were to determine the safety of stem cell harvesting and to determine the surface phenotypic and functional characteristics of both freshly harvested and cryopreserved stem cells that have been mobilized into the peripheral blood subsequent to the administration of Filgrastim in subjects at various stages of HIV-1 infection. Results of this trial have not yet been published.
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