ACTG 285 STEM CELL MOBILIZATION AND HARVESTING WITH FILGRASTIM

使用 FILGRASTIM 动员和收获 ACTG 285 干细胞

• 批准号: 6114147
• 负责人: Robert Turner Schooley
• 金额: $ 3.22万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114147
• 关键词: cell motility; clinical research; colony stimulating factor; hematopoietic stem cells; human subject; recombinant proteins

ACTG 285 - A Pilot Study of Stem Cell Mobilization and Harvesting from the Peripheral Blood Using Filgrastim. The study explored whether the ability of Filgrastim to mobilize CD34+ stem cells into the peripheral blood differs markedly among individuals with various stages of HIV-1 infection and HIV-1 seronegative individuals. The study's objectives were to determine the safety of stem cell harvesting and to determine the surface phenotypic and functional characteristics of both freshly harvested and cryopreserved stem cells that have been mobilized into the peripheral blood subsequent to the administration of Filgrastim in subjects at various stages of HIV-1 infection. Results of this trial have not yet been published.

ACTG 285 -使用非格司亭从外周血中动员和收获干细胞的初步研究。该研究探讨了非格司亭动员CD 34+干细胞进入外周血的能力是否在不同阶段的HIV-1感染个体和HIV-1血清阴性个体之间存在显著差异。该研究的目的是确定干细胞收获的安全性，并确定在HIV-1感染的各个阶段的受试者中给予非格司亭后，新鲜收获和冻存的干细胞的表面表型和功能特征，这些干细胞已动员到外周血中。这项试验的结果尚未公布。