THE CARDIAC CONSEQUENCES OF HEMISPHERIC STROKE

半球中风的心脏后果

• 批准号: 6297515
• 负责人: STEPHEN M OPPENHEIMER
• 金额: $ 0.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297515
• 关键词: cardiovascular disorder diagnosis; clinical research; heart disorder; heart function; human subject; hypertension; medical complication; outcomes research; stroke

As of January 16, 1998, we have recruited 138 stroke patients and TIA patients into the study. 616 patients have been assessed for inclusion, representing an inclusion frequency of 23%. The principle reason for refusal to participate in the study was a lack of interest on the part of the patient or relatives or a premature discharge from hospital before assessment could take place. This latter usually meant that patients were discharged by attending physicians other than those in the Cerebrovascular Program within 24 hours of admission. The enrolled patients are generally representative of those not enrolled in the study. More african americans were enrolled in the study than white individuals, representing the racial distribution in the Baltimore area. An equal number of male and female patients were recruited, which once again is representative of the nonenrolled group. As before, the principle reasons for non-enrollment in the study are significant obtundation, significant concomitant disease and radiological evidence of previous stroke. The majority of patients included in this study suffered a hemispheric infarct. Approximately 7% of patients had a hemispherical brain stem hemorrhage. This is consistent with the incidence of cerebral hemorrhage in the general population. The distribution and nature of strokes is similar in the patients included in the study and those not enrolled in the study, once again emphasizing that the study population is representative of the general population of stroke patients admitted to the hospital. Left and right hemispheric and brain stem strokes are equally represented without laterality predominance. The distribution of stroke is similar in those patients not enrolled in the study as compared to those enrolled in the study, once again emphasizing the lack of bias. Nearly 100% of patients underwent cardiac autonomic testing, Holter tape assessment and late potential analysis. Transesophageal echocardiography was performed in 76% of patients in the study, but not performed in 24%, either because this was refused by the patient or was considered to be contraindicated by the cardiology staff, or because these patients had had a recent transesophageal echocardiogram. Adenosine thallium scanning was performed in nearly 60% of the patients. In those patients in whom it was not performed, there was a documented history of coronary artery disease. Approximately 30% of patients did not attend a follow-up assessment.

截至1998年1月16日，我们招募了138名中风和TIA患者 患者进入研究。 616例患者已被评估纳入， 包含频率为23%。 的主要原因 拒绝参加这项研究是因为缺乏兴趣的一部分， 患者或亲属的死亡或提前出院 才能进行评估。 后者通常意味着， 病人出院的主治医生以外的那些在 入院后24小时内的脑血管计划。 入组 患者通常代表未入选的患者， study. 参加这项研究的非裔美国人比白色人多 代表巴尔的摩地区的种族分布。 招募了相同数量的男性和女性患者， 再次代表未登记组。 和以前一样， 未入组研究的主要原因是重要的 闭塞、重大伴随疾病和放射学证据 以前的中风。 本研究纳入的大多数患者 大脑半球梗塞 大约7%的患者有 半球性脑干出血 这符合 一般人群中脑出血的发病率。 的 纳入的患者中卒中的分布和性质相似 在研究中和那些没有参加研究，再次强调 研究人群代表一般人群 入院的中风患者中。 左右半球 和脑干中风的代表性相同，没有偏侧性 优势 这些患者中卒中的分布相似 与入组研究的患者相比，未入组研究的患者， 再次强调了没有偏见。 几乎100%的患者 进行心脏自主神经测试，霍尔特磁带评估和晚期 潜力分析 经食管超声心动图检查， 研究中76%的患者，但24%的患者未进行， 患者拒绝或认为有禁忌 或者因为这些病人最近有过 经食管超声心动图 腺苷铊扫描 在近60%的患者中进行。 在那些患者中， 未进行，有记录的冠状动脉病史 疾病 大约30%的患者没有参加随访 考核