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Musculoskeletal functional ability in three diverse Sub-Saharan Africa Populations; assessing muscle strength & function to understand healthy ageing

撒哈拉以南非洲三种不同人群的肌肉骨骼功能能力；

基本信息

批准号：
MR/W003961/1
负责人：
Kate Ward
金额：
$ 104.25万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FW003961%2F1
关键词：
Musculoskeletal functional ability three diverse

项目摘要

Around the world people are living longer than ever before. There are now 1 billion people aged over 60 years. In Africa, rising life expectancy is most rapid. The United Nations declaration of the Decade of Health Ageing 2021-2030 states there has never been a timelier opportunity to act to ensure the health of ageing adults, their families and communities. But ageing brings risk of disease, with muscles, bones and joints commonly affected (musculoskeletal disease), which limits walking and daily life. Often diseases exist together, such as with HIV and/or diabetes, this is known as multimorbidity. Multimorbidity is a high priority for global health research. Importantly, one third of all multimorbidity cases across the world include musculoskeletal disease. Currently musculoskeletal diseases account for disability than cancer and heart disease combined. Loss of muscle strength and function is a common manifestation of ageing (known as sarcopenia), which leads to falls and fragility fractures (broken bones from low impact injuries), disability, frailty, and sometimes death. Despite this, little is known about how muscle ages in people living in sub-Saharan Africa (SSA), nor the risk factors for muscle loss or the impact on quality of life. We will study three different populations in The Gambia, Zimbabwe and South Africa. Aiming to:i. How commonly muscle strength is impaired, physical functional is limited and sarcopenia is experienced.ii. Understand to what extent losses in muscle strength and ability reduce the ability to perform activities of daily life, increase the risk of frailty and disability and how these impact quality of life.iii. Identify clinical, nutritional and metabolic risk factors for losses muscle function, to inform approaches to reduce future disability, and promote healthy ageing in SSA. Work package 1: What is the epidemiology of muscle strength, mass and function in each country? We collaborate with a team currently planning extensive community surveys in The Gambia, Zimbabwe and South Africa, which will measure spine fractures in 5040 men and women aged 40 years and over. We have a unique and time-limited opportunity to add to these surveys, data collection and detailed measurements of muscle strength, mass and function, to answer our specific study questions. We will collect data from questionnaires (e.g. joint and back pain, ability to work around the house, quality of life), body composition scans (to quantify fat and muscle mass), X-rays (to quantify osteoarthritis), muscle strength, walking and balance tests (to measure frailty), and blood tests. We will quantify levels of all musculoskeletal multimorbidities including sarcopenia, and determine how these affect disability and quality of life. Work package 2: What are the clinical, nutritional and metabolic risk factors for low muscle strength, mass and function? Identifying risk factors for muscle impairment will aid understanding of the mechanisms underlying muscle dysfunction and highlight biomarkers that can predict disease and disability, with potential use in clinical settings. We will examine clinical (e.g. HIV, diabetes, physical inactivity, osteoarthritis) and nutritional risk factors (e.g. malnutrition, food insecurity, obesity), and measure 184 markers of metabolism and inflammation using the latest proteomic analysis of blood samples, to see which predict age-related losses in muscle.We will feedback our findings to local communities, national health leads and policy makers, and international researchers.This project grant offers a unique and highly-cost effective opportunity, taking advantage of a funded research platform. This MRC investment would permit detailed and novel study of muscle in some of the most rapidly ageing populations in the world. This presents a time-limited opportunity to answer these important research questions focusing on muscle health and functional ability.

全世界人们的寿命比以往任何时候都长。现在60岁以上的人口有10亿。在非洲，预期寿命的增长最为迅速。《联合国2021-2030年健康老龄化十年宣言》指出，采取行动确保老年人、其家庭和社区健康的时机从未如此及时。但衰老会带来疾病的风险，肌肉、骨骼和关节通常会受到影响（肌肉骨骼疾病），这限制了行走和日常生活。疾病通常同时存在，例如艾滋病毒和/或糖尿病，这被称为多病。多发病是全球卫生研究的一个高度优先事项。重要的是，全世界三分之一的多病病例包括肌肉骨骼疾病。目前，肌肉骨骼疾病造成的残疾比癌症和心脏病加起来还要多。肌肉力量和功能的丧失是衰老的一种常见表现（称为肌肉减少症），它会导致跌倒和脆性骨折（低冲击力损伤导致的骨折）、残疾、虚弱，有时甚至死亡。尽管如此，对于生活在撒哈拉以南非洲（SSA）的人们的肌肉是如何衰老的，以及肌肉损失的风险因素或对生活质量的影响，人们知之甚少。我们将研究冈比亚、津巴布韦和南非三种不同的人口。目标:我。肌肉力量受损、身体功能受限和肌肉减少症的常见程度。了解肌肉力量和能力的丧失在多大程度上降低了日常生活活动的能力，增加了虚弱和残疾的风险，以及这些如何影响生活质量。确定肌肉功能丧失的临床、营养和代谢风险因素，告知减少未来残疾的方法，并促进SSA的健康老龄化。工作包1：每个国家肌肉力量、质量和功能的流行病学情况如何？我们与一个团队合作，目前正在计划在冈比亚、津巴布韦和南非进行广泛的社区调查，这将测量5040名40岁及以上的男性和女性的脊柱骨折。我们有一个独特的、时间有限的机会来补充这些调查、数据收集和肌肉力量、质量和功能的详细测量，以回答我们具体的研究问题。我们将从问卷调查（例如关节和背部疼痛、在家里工作的能力、生活质量）、身体成分扫描（量化脂肪和肌肉质量）、x光（量化骨关节炎）、肌肉力量、行走和平衡测试（衡量虚弱程度）和血液测试中收集数据。我们将量化包括肌肉减少症在内的所有肌肉骨骼多病的水平，并确定这些疾病如何影响残疾和生活质量。工作包2：低肌肉力量、质量和功能的临床、营养和代谢危险因素是什么？识别肌肉损伤的危险因素将有助于理解肌肉功能障碍的机制，并突出可以预测疾病和残疾的生物标志物，具有潜在的临床应用价值。我们将检查临床（如艾滋病毒、糖尿病、缺乏运动、骨关节炎）和营养风险因素（如营养不良、食品不安全、肥胖），并使用最新的血液样本蛋白质组学分析测量184种代谢和炎症标志物，看看哪些能预测与年龄相关的肌肉损失。我们将把我们的发现反馈给当地社区、国家卫生领导和政策制定者以及国际研究人员。该项目赠款提供了一个独特的、高成本效益的机会，利用资助的研究平台。这项MRC投资将允许对世界上一些老龄化速度最快的人群进行详细而新颖的肌肉研究。这提供了一个时间有限的机会来回答这些关注肌肉健康和功能能力的重要研究问题。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Impaired Bone Architecture in Peripubertal Children With HIV, Despite Treatment With Antiretroviral Therapy: A Cross-Sectional Study From Zimbabwe.

DOI：
10.1002/jbmr.4752
发表时间：
2023-03
期刊：
JOURNAL OF BONE AND MINERAL RESEARCH
影响因子：
6.2
作者：
Mukwasi-Kahari, Cynthia;Rehman, Andrea M.;Breasail, Micheal O.;Rukuni, Ruramayi;Madanhire, Tafadzwa;Chipanga, Joseph;Stranix-Chibanda, Lynda;Micklesfield, Lisa K.;Ferrand, Rashida A.;Ward, Kate A.;Gregson, Celia L.
通讯作者：
Gregson, Celia L.

Sex-specific associations between cardiovascular risk factors and physical function: the Gambian Bone and Muscle Ageing Study.