Consortium to Research Individual, Interpersonal, and Social influences in Pain (CRIISP)

个人、人际和社会疼痛影响研究联盟 (CRIISP)

• 批准号: MR/W004151/1
• 负责人: Edmund Keogh
• 金额: $ 487.27万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW004151%2F1
• 关键词: Consortium; Research; Individual; Interpersonal; Social

(i) Aims and objectivesPain that lasts a long time (is chronic) takes apart lives, relationships and families. Although biological signals can help understand why pain happens, they do not fully account for the experiences people have, or why pain develops the way it does. Psychological and social factors, such as thoughts and feelings, personal relationships, and lifestyle, can also affect chronic pain. However, we do not yet know which of these psychological and social mechanisms are most important, or how they combine with biological signals to affect chronic pain. Our aim is to determine the psychosocial mechanisms underpinning chronic pain. Our objective is to create a clearer account of how, and in what way, psychosocial factors (interacting with biology) affect pain: what makes chronic pain start, keep going, get better or get worse. In doing so, we will also identify ways to prevent chronic pain from happening, and reduce the negative effects that pain can have on people's lives. (ii) Data to be collectedWe will focus on how people think and feel about pain, how others affect their pain, and consider the wider social and environmental influences on pain. These psychosocial mechanisms will in turn be described in the context of physiological and biomedical dimensions of chronic pain. Our planned work involves people with pain at each stage to ensure our work is guided by the way pain affects people's lives. We will start by exploring the existing evidence, to identify what matters most, including what measures and methods best reflect lived experience. We will ask people with pain which of these factors matter most, and test them in existing large datasets. We will run new studies on the psychological and social factors that hold greatest promise. We will explore how the way people think and behave contributes to pain, and observe how people live their lives with pain. We will study the ways people adapt to live well with pain, and identify the part played in chronic pain by the factors we are interested in. (iii) Benefits of the consortiumA consortium approach allows us to think big. It gives us a rare opportunity to change how we think about pain and how we research it. To achieve these ambitious goals, we need to bring together expertise from different scientific disciplines, alongside people with pain, and in a way that has not previously been possible. The Advanced Pain Discovery Platform (APDP) not only allows us to do this, but also offers us an unprecedented prospect of working consistently at a conceptual level, to generate data and test ideas. It also allows for cross-consortium working, to stimulate and evaluate new ideas and spot opportunities for future pain research and discovery.(iv) Legacy and/or sustainability of the network Our primary contribution will be to identify the psychological and social factors that are most important for understanding pain. We will develop new ways to study pain, new measures of pain and its impacts, and most importantly identify key psychosocial mechanisms of pain, showing how they work alongside biology to promote or limit pain. We will provide guidance about these psychosocial mechanisms, and place this resource within the APDP, for use by the wider interdisciplinary pain research community, including those who wish to incorporate psychosocial factors in medical-epidemiological, clinical, or human genotyping studies. Through our work, and the partnerships that generated it, we will open new, broad avenues of pain research that will develop better ways to help people to live well with less pain.

(i)目的和目标持续很长时间（慢性）的疼痛会破坏生活、关系和家庭。虽然生物信号可以帮助理解疼痛发生的原因，但它们并不能完全解释人们的经历，或者为什么疼痛会以这种方式发展。心理和社会因素，例如思想和感受、个人关系和生活方式，也会影响慢性疼痛。然而，我们还不知道这些心理和社会机制中哪些是最重要的，或者它们如何与生物信号联合收割机结合来影响慢性疼痛。我们的目的是确定慢性疼痛的心理社会机制。我们的目标是更清楚地说明心理社会因素（与生物学相互作用）如何以及以何种方式影响疼痛：是什么使慢性疼痛开始，持续，好转或恶化。在此过程中，我们还将确定预防慢性疼痛发生的方法，并减少疼痛对人们生活的负面影响。(ii)我们将关注人们如何思考和感受疼痛，其他人如何影响他们的疼痛，并考虑更广泛的社会和环境对疼痛的影响。这些心理社会机制将反过来在慢性疼痛的生理和生物医学层面的背景下进行描述。我们计划的工作涉及每个阶段的疼痛患者，以确保我们的工作以疼痛影响人们生活的方式为指导。我们将从探索现有的证据开始，以确定什么最重要，包括什么措施和方法最能反映生活经验。我们将询问疼痛患者这些因素中哪些最重要，并在现有的大型数据集中进行测试。我们将对最有希望的心理和社会因素进行新的研究。我们将探索人们的思维和行为方式如何导致疼痛，并观察人们如何在痛苦中生活。我们将研究人们如何适应疼痛，并确定我们感兴趣的因素在慢性疼痛中所起的作用。(iii)联合体的好处联合体的方法使我们能够大胆思考。它为我们提供了一个难得的机会来改变我们对疼痛的看法和研究方式。为了实现这些雄心勃勃的目标，我们需要将来自不同科学学科的专业知识与疼痛患者一起汇集在一起，并且以一种前所未有的方式。高级疼痛发现平台（APDP）不仅允许我们这样做，而且还为我们提供了一个前所未有的前景，即在概念层面上持续工作，以生成数据和测试想法。它还允许跨联盟工作，以刺激和评估新的想法，并为未来的疼痛研究和发现机会。(iv)网络的遗产和/或可持续性我们的主要贡献将是确定对理解疼痛最重要的心理和社会因素。我们将开发新的方法来研究疼痛，疼痛及其影响的新措施，最重要的是确定疼痛的关键心理社会机制，显示它们如何与生物学一起促进或限制疼痛。我们将提供有关这些心理社会机制的指导，并将此资源置于APDP中，供更广泛的跨学科疼痛研究社区使用，包括那些希望将心理社会因素纳入医学流行病学，临床或人类基因分型研究的人。通过我们的工作，以及由此产生的伙伴关系，我们将开辟新的，广阔的疼痛研究途径，开发更好的方法来帮助人们生活得更好，减少疼痛。

项目成果

The establishment, maintenance, and adaptation of high- and low-impact chronic pain: a framework for biopsychosocial pain research.

• DOI: 10.1097/j.pain.0000000000002951
• 发表时间: 2023-10-01
• 期刊: Pain
• 影响因子: 7.4