CALCIUM KINETICS WITH HISTORIES OF OSTEOPOROSIS

骨质疏松症历史中的钙动力学

• 批准号: 6114242
• 负责人: Kimberly O O'Brien
• 金额: $ 2.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114242
• 关键词: adolescence (12-20); bone density; bone metabolism; calcium metabolism; clinical research; dietary calcium; family genetics; female; human subject; nutrition related tag; osteoporosis

A family history of low bone mass is a risk factor for the development of osteoporosis but the mechanisms responsible for this finding are not know. The potential for a family history of low bone mass to alter calcium metabolism may be most apparent in young girls because the majority of bone mass is obtained prior to the age of 16 years in females. The goals of this study are to determine if young girls from families with histories of osteoporosis have alternations in their ability to absob calcium and deposit it into bone. For three weeks before each clinical study, each girl consumes a high calcium diet chosen to provide the amount of calcium which is currently being recommended for adolescent girls. On the day of each study two special forms of calcium tracers are given to each girl so that we can follow the clearance of calcium into bone over the following 5 days. To date,we have completed the clinical study in 3 girls from families with strong histories of osteoporosis, and 7 more girls will be recruited for this study. Although it is too early to comment on our results, this information will provide useful information on the recommendations for children from osteroporotic families.

低骨量家族史是发育的危险因素 骨质疏松症，但导致这一发现的机制并不明确 知道。 低骨量家族史有可能改变 钙代谢在年轻女孩中可能最为明显，因为 大部分骨量是在16岁之前获得的 女性。 这项研究的目标是确定年轻女孩是否来自 有骨质疏松症家族史的人，其骨质疏松症的情况会发生变化。 吸收钙并将其沉积到骨骼中的能力。三个星期 在每次临床研究之前，每个女孩都会摄入高钙饮食 选择提供当前正在提供的钙量 推荐给青春期的女孩。 每次学习当天有两个特别的 给每个女孩提供各种形式的钙示踪剂，以便我们可以追踪 在接下来的 5 天内钙被清除到骨骼中。 到 迄今为止，我们已经完成了对 3 名来自患有此类疾病的家庭的女孩的临床研究。 患有骨质疏松症的严重病史，另外 7 名女孩将被招募 这项研究。 虽然现在评论我们的结果还为时过早，但这 信息将提供有关建议的有用信息 来自骨质疏松症家庭的孩子。