CALCIUM KINETICS WITH HISTORIES OF OSTEOPOROSIS

低骨量的家族史是发展的危险因素， 骨质疏松症，但负责这一发现的机制尚不清楚。 低骨量家族史改变钙的可能性 新陈代谢在年轻女孩中可能最明显，因为大多数 女性在16岁之前获得骨量。 的目标 这项研究的目的是确定来自有病史家庭的年轻女孩 骨质疏松症的患者在吸收钙的能力上有变化， 存款到骨头里。每次临床研究前三周， 女孩消耗高钙饮食选择提供的钙量 目前正在推荐给青春期女孩。 的当天 每项研究都给每个女孩两种特殊形式的钙示踪剂， 我们可以在接下来的5年里追踪钙进入骨骼的过程， 天 到目前为止，我们已经完成了3名女孩的临床研究， 有骨质疏松症病史的家庭，还有7个女孩将 为这项研究招募。 虽然现在评论我们的 结果，这些信息将提供有关 骨量的遗传性，并可能有助于确定钙的摄入量 对患有骨质疏松症家庭的儿童的建议。

A family history of low bone mass is a risk factor for the development of osteoporosis but the mechanisms responsible for this finding are not know. The potential for a family history of low bone mass to alter calcium metabolism may be most apparent in young girls because the majority of bone mass is obtained pior to the age of 16 years in females. The goals of this study are to determine if young girls from families with histories of osteoporosis have alternations in their ability to absorb calcium and deposit it into bone. For three weeks before each clinical study, each girl consumes a high calcium diet chosen to provide the amount of calcium which is currently being recommended for adolescent girls. On the day of each study two special forms of calcium tracers are given to each girl so that we can follow the clerance of calcium into bone over the following 5 days. To date, we have completed the clinical study in 3 girls from families with strong hisstories of osteoporosis, and 7 more girls will be recruited for this study. Although it is too early to comment on our resluts, this information will provide useful information on the heritability of bone mass and may help in defining calcium intake recommendations for children from ostroporotic families.