RADIATION EXPOSURE AND INJURY ASSESSMENT

辐射暴露和伤害评估

• 批准号: 6115195
• 负责人: William W Au
• 金额: $ 3.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115195
• 关键词: DNA damage; DNA repair; biomarker; blood chemistry; case history; chromosome aberrations; clinical research; human genetic material tag; human subject; occupational hazard; prognosis; radiation dosage; radiation genetics; radiation hazard; whole body imaging /scanning

Accurate assessment of radiation exposure doses and injury soon after exposure is critical for use in predicting short and long term health consequences. We intend to evaluate accidentally exposed workers by a variety of laboratory techniques. Specifically, analytical techniques will be used to quantitate internal radiation exposure dose using whole body counting and biologic effects by genetic analysis. For the latter, blood samples will be collected and used to evaluate for presence of chromosome aberrations and abnormalities in DNA repair. Standard health evaluation will include history, physical examination and clinical laboratory determinations. using a combination of indicators of exposure, and biological and health effects, our study should provide reliable information for evaluation of short and lnog term health risks.

准确评估辐射照射剂量和照射后不久的损伤对于预测短期和长期健康后果至关重要。 我们打算通过各种实验室技术来评估意外暴露的工人。 具体而言，将使用分析技术通过全身计数和遗传分析的生物效应来定量内部辐射照射剂量。 对于后者，将采集血样并用于评价是否存在染色体畸变和DNA修复异常。 标准健康评估将包括病史、体格检查和临床实验室测定。 我们的研究结合了暴露指标、生物和健康影响，应能为评估短期和长期健康风险提供可靠的资料。