RADIATION EXPOSURE AND INJURY ASSESSMENT

准确评估辐射照射剂量和照射后不久的损伤对于预测短期和长期健康后果至关重要。我们打算用各种实验室技术来评估意外暴露的工人。具体而言，分析技术将用于通过全身计数和遗传分析的生物效应来量化内辐射照射剂量。对于后者，将收集血液样本并用于评估染色体畸变和DNA修复异常的存在。标准的健康评估将包括病史、体格检查和临床实验室测定。综合使用暴露指标、生物效应和健康效应，我们的研究将为评估短期和长期健康风险提供可靠的信息。

Accurate assessment of radiation exposure doses and injury soon after exposure is critical for use in predicting short and long term health consequences. We intend to evaluate accidentally exposed workers by a variety of laboratory techniques. Specifically, analytical techniques will be used to quantitate internal radiation exposure dose using whole body counting and biologic effects by genetic analysis. For the latter, blood samples will be collected and used to evaluate for presence of chromosome aberrations and abnormalities in DNA repair. Standard health evaluation will include history, physical examination and clinical laboratory determinations. using a combination of indicators of exposure, and biological and health effects, our study should provide reliable information for evaluation of short and lnog term health risks.