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INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCY

INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCY
妊娠期胰岛素抵抗和葡萄糖代谢
批准号：
6115353
负责人：
Patrick Catalano
金额：
$1.92万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115353
关键词：
adipose tissue body composition clinical research drug tolerance fats female gestational age gestational diabetes mellitus glucose metabolism human pregnant subject human subject insulin sensitivity /resistance lipid metabolism longitudinal human study obesity pregnancy pregnancy circulation

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中文摘要
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英文摘要
The long term objectives are to understand the relationship of pregravid maternal lipid metabolism and maternal metabolic adaptations during pregnancy at the system and cellular level. The specific aims of this proposal are to : evaluate the longitudinal changes in maternal insulin sensitivity as it relates to maternal lipid metabolism and fat accretion in lean and obese women with normal glucose tolerance and gestational diabetes; evaluate the alterations in maternal lipid metabolism in late pregnancy in relationship to neonatal body composition; and, identify the cellular mechanisms underlying decreased insulin sensitivity in adipose tissue during late gestation in normal glucose tolerance and gestational diabetes.
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