INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCY

妊娠期胰岛素抵抗和葡萄糖代谢

• 批准号: 6115353
• 负责人: Patrick Catalano
• 金额: $ 1.92万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115353
• 关键词: adipose tissue; body composition; clinical research; drug tolerance; fats; female; gestational age; gestational diabetes mellitus; glucose metabolism; human pregnant subject; human subject; insulin sensitivity /resistance; lipid metabolism; longitudinal human study; obesity; pregnancy; pregnancy circulation

The long term objectives are to understand the relationship of pregravid maternal lipid metabolism and maternal metabolic adaptations during pregnancy at the system and cellular level. The specific aims of this proposal are to : evaluate the longitudinal changes in maternal insulin sensitivity as it relates to maternal lipid metabolism and fat accretion in lean and obese women with normal glucose tolerance and gestational diabetes; evaluate the alterations in maternal lipid metabolism in late pregnancy in relationship to neonatal body composition; and, identify the cellular mechanisms underlying decreased insulin sensitivity in adipose tissue during late gestation in normal glucose tolerance and gestational diabetes.

长期目标是在系统和细胞水平上了解孕前母体脂代谢与孕期母体代谢适应的关系。这项建议的具体目的是：评估与糖耐量正常和妊娠期糖尿病的瘦身和肥胖妇女的母体脂肪代谢和脂肪堆积有关的母体胰岛素敏感性的纵向变化；评估妊娠晚期母体脂代谢的变化与新生儿身体成分的关系；以及确定正常糖耐量和妊娠期糖尿病妊娠晚期脂肪组织胰岛素敏感性降低的细胞机制。