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COMPARISON OF STNFR55 IGG WITH ORAL METHOTREXATE IN ACTIVE RHEUMATOID ARTHRITIS

COMPARISON OF STNFR55 IGG WITH ORAL METHOTREXATE IN ACTIVE RHEUMATOID ARTHRITIS
STNFR55 IGG 与口服甲氨蝶呤治疗活动性类风湿关节炎的比较
批准号：
6115482
负责人：
NANCY L LANE
金额：
$3.1万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115482
关键词：
clinical research cytokine receptors drug screening /evaluation human subject human therapy evaluation immunoconjugates immunoglobulin G methotrexate recombinant proteins rheumatoid arthritis skeletal disorder chemotherapy tumor necrosis factor alpha

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英文摘要
Ro 45-2081 is a recombinent molecule that consists of the complete extracellular domain of the human 55 KD TNF alpha receptor and an immunoglobulin IgG heavy chain sequence. It is designed to have a longer in vivo half-life and higher TNF neutralizing capability than a natural TNF inhibitor. Previous studies have utilized intravenous infusion in patients with rheumatoid arthritis and have demonstrated salutory effects. The current study will utilize a subcutaneous route of administration either given alone or in combination with methotrexate and will evaluate the clinical and functional manifestations of rheumatoid arthritis over a 12 week period.
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