TESTOSTERONE REPLACEMENT INCREASES FAT FREE MASS & MUSCLE SIZE

睾酮替代品可增加去脂体重

• 批准号: 6118492
• 负责人: SHALENDER BHASIN
• 金额: $ 0.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118492
• 关键词: biomedical resource; drug /agent; endocrine gland /system; human subject; male; musculoskeletal system; physical fitness; proteins; spectrometry

The objective of this study was to determine the effects of replacement doses of testosterone on fat-free mass and muscle size in healthy hypogonadal men, in the setting of controlled nutritional intake and exercise level. Seven hypogonadal men, 19-47 years of age, after at least a 12 week washout from previous androgen therapy, were treated for ten weeks with testosterone enanthate 100 mg/wk by intra-muscular injections. Body weight, fat-free mass measured by underwater weighing and deuterated water dilution, and muscle size measured by magnetic resonance imaging were assessed before and after treatment. Energy and protein intake were standardized at 35 kcal/kg/day and 1.5 g/kg/day, respectively. Body weight increased significantly from 79.2(5 y to 83.7(5.7 kg after 10 weeks of testosterone replacement therapy (weight gain, 4.5(0.6 kg, P=0.00064). Fat-free mass measured by underwater weighing, increased from 56.0(2.5 to 60.9(2.2 kg (change, +5.0(0.7 kg, P=0.0004), but pe rcent fat did not significantly change. Similar increases in fat-free mass were observed with the deuterated water method. Measures of protein dynamics including L (1--13-C)leucine turnover, leucine oxidation, and non-oxidative disappearance of leucine did not significantly change after 10 weeks of treatment.

本研究的目的是确定 睾酮替代剂量对无脂肪质量和肌肉大小的影响 健康的性腺功能减退的男性，在控制营养的情况下， 摄入量和运动水平。 七名性腺功能减退的男性，19-47岁， 在既往雄激素治疗洗脱至少12周后， 用庚酸睾酮100 mg/wk治疗10周， 肌肉注射 体重，通过以下方法测量的去脂质量 水下称重和氘水稀释，以及肌肉大小 通过磁共振成像测量，评估前后 治疗 能量和蛋白质摄入量标准化为35 kcal/kg/天和1.5 g/kg/天。 体重增加 10周后，从79.2（5年）显著增加至83.7（5.7 kg 睾酮替代治疗（体重增加，4.5（0.6 kg，P=0.00064）。 通过水下称重测量的无脂肪质量从56.0（2.5 增加到60.9（2.2 kg）（变化，+5.0（0.7 kg，P=0.0004），但脂肪百分比增加 没有显著变化。 类似的无脂肪质量增加， 用氘代水方法观察。 蛋白质测量 动力学包括L（1--13-C）亮氨酸周转，亮氨酸氧化， 亮氨酸的非氧化性消失没有显著改变 治疗10周后。