GLUTAMINE METABOLISM IN HUMAN NEONATES

本提案的总体目标是阐明 谷氨酰胺代谢的新生儿，并确定如何早产， 手术压力改变了这些通路。 谷氨酰胺，一种重要的燃料， 淋巴细胞和肠上皮细胞，可能是一个不可或缺的氨基 早产儿和手术应激婴儿的胃酸。 因此，委员会认为， 确定这些婴儿合成谷氨酰胺的能力， 调节谷氨酰胺从现有的身体蛋白质中的释放， 重要. 谷氨酰胺补充剂可能在以下方面发挥关键作用： 支持最佳的蛋白质增长，从肠道损伤中恢复， 免疫功能的变化。 具体 该提案的目的是确定从头谷氨酰胺 谷氨酰胺从身体蛋白质的合成和释放被改变， 早产和手术压力：1）基础状态2）响应 肠外营养的提供和3）响应 提供补充谷氨酰胺的肠外营养。 这些 将利用稳定同位素示踪剂实现具体目标。 执行 这些研究将提供对谷氨酰胺代谢的深入了解， 最终，可以作为改善营养管理的基础， 早产儿和手术应激的婴儿。

The overall objective of this proposal is to elucidate the pathways of glutamine metabolism in neonates and to determine how prematurity and surgical stress alter these pathways. Glutamine, an important fuel for lymphocytes and intestinal epithelial cells, may be an indispensable amino acid in premature and surgically stressed infants. Consequently, determining the capacity of these infants to synthesize glutamine and the regulation of the release of glutamine from existing body protein is important. Glutamine supplementation may play a critical role in supporting optimal protein accretion, recovery from intestinal injury, and immune function in these particularly vulnerable infants. The specific aims of this proposal are to determine how rates of de novo glutamine synthesis and release of glutamine from body protein are altered by prematurity and surgical stress in: 1) the basal state 2) in response to the provision of parenteral nutrition and 3) in response to the provision of parenteral nutrition with supplemental glutamine. These specific aims will be pursued using stable isotope tracers. Performing these studies will provide insight into the metabolism of glutamine and ultimately, may serve as the basis for improved nutritional management of premature and surgically stressed infants.