UNMASKING CRF ACTH CORTISOL AXIS IN HYPOTHALAMIC AMENORRHEA

揭示下丘脑性闭经中的 CRF ACTH 皮质醇轴

• 批准号: 6117996
• 负责人: SAMUEL S YEN
• 金额: $ 1.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117996
• 关键词: adrenocorticotropic hormone; alpha adrenergic receptor; amenorrhea; clinical research; corticotropin releasing factor; female; gonadotropin releasing factor; hormone regulation /control mechanism; human subject; hypercortisolism; hypothalamus; luteinizing hormone; neuroendocrine system; women's health

Define mechanisms underlying neuroendocrine aberrations in women with functional hypothalamic amenorrhea, test whether development of hypercortisolemia in amenorrhea is mediated by increased hypothalamic CRF secondary to alpha-adrenergic activation and that inappropriate input of CRF may inhibit GnRH-LH pulsatility.

明确功能性下丘脑性闭经妇女神经内分泌异常的潜在机制，检测闭经时高皮质醇血症的发生是否由继发于α-肾上腺素能激活的下丘脑CRF增加介导，以及CRF的不适当输入可能抑制GnRH-LH脉动。