HORMONE REPLACEMENT AFFECTS ROLE OF DHEA IN WOMEN OF ADVANCED AGE

激素替代会影响高龄女性 DHEA 的作用

• 批准号: 6279156
• 负责人: SAMUEL S YEN
• 金额: $ 1.43万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279156
• 关键词: aging; clinical research; dehydroepiandrosterone; estrogens; female; hormone therapy; human subject; human therapy evaluation; immunoregulation; oral administration; transdermal drug delivery; women's health

To test if the beneficial effects of dhea seen in men (increased muscle mass and decreased body fat) but not seen in women is related to oral hormone replacement therapy. Transdermal estrogen therapy versus oral estrogen therapy may positively influence the anabolic and immune enhancing effects of DEHA replacement in aging women.

为了测试dhea在男性中的有益效果（增加肌肉 体重和身体脂肪减少），但在女性中未见与口服 激素替代疗法经皮雌激素治疗与口服 雌激素治疗可能会积极影响合成代谢和免疫 增强老年妇女DEHA替代的效果。