DEPRESSION EFFECT OF REM SLEEP SUPPRESSION BY MAOI PHENELZINE

MAOI 苯乙肼抑制快速眼动睡眠的抑郁效应

• 批准号: 6265188
• 负责人: JOHN C GILLIN
• 金额: $ 1.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265188
• 关键词: REM sleep; adrenocorticotropic hormone; antidepressants; body temperature; circadian rhythms; clinical research; cortisol; dreams; drug administration rate /duration; drug screening /evaluation; electroencephalography; emotions; human subject; human therapy evaluation; major depression; melatonin; memory; mental disorder chemotherapy; neuroendocrine system; phenelzine; polygraphy

To extend knowledge on the regulation and the functions of sleep in health and disease, this study will investigate the effect of the antidepressant phenelzine (Nardil) for at least 5 weeks in patients with major depression. Effect on mood, memory, polygraphic sleep measures, the sleep EEG, circadian phase position (assessed by neuroendocrine measures melatonin, ACTH, cortisol and body temperature) and dream recall will be assessed.

为了扩展有关健康和疾病中睡眠功能的知识，这项研究将研究抗抑郁剂苯嗪（Nardil）至少5周对严重抑郁症患者的影响。将评估情绪，记忆记忆，聚生睡眠度量，睡眠脑电图，昼夜节相位位置（通过神经内分泌测量方法评估褪黑激素，ACTH，皮质醇和体温）和梦想回忆。