DEPRESSION EFFECT OF REM SLEEP SUPPRESSION BY MAOI PHENELZINE

MAOI 苯乙肼抑制快速眼动睡眠的抑郁效应

• 批准号: 6265188
• 负责人: JOHN C GILLIN
• 金额: $ 1.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265188
• 关键词: REM sleep; adrenocorticotropic hormone; antidepressants; body temperature; circadian rhythms; clinical research; cortisol; dreams; drug administration rate /duration; drug screening /evaluation; electroencephalography; emotions; human subject; human therapy evaluation; major depression; melatonin; memory; mental disorder chemotherapy; neuroendocrine system; phenelzine; polygraphy

To extend knowledge on the regulation and the functions of sleep in health and disease, this study will investigate the effect of the antidepressant phenelzine (Nardil) for at least 5 weeks in patients with major depression. Effect on mood, memory, polygraphic sleep measures, the sleep EEG, circadian phase position (assessed by neuroendocrine measures melatonin, ACTH, cortisol and body temperature) and dream recall will be assessed.

为了扩展对睡眠在健康和疾病中的调节和功能的认识，本研究将研究抗抑郁药苯乙肼（Nardil）对重度抑郁症患者至少5周的影响。将评估对情绪、记忆、多导睡眠测量、睡眠EEG、昼夜节律相位（通过神经内分泌测量褪黑激素、ACTH、皮质醇和体温评估）和梦回忆的影响。