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DEPRESSION EFFECT OF REM SLEEP SUPPRESSION BY MAOI PHENELZINE

DEPRESSION EFFECT OF REM SLEEP SUPPRESSION BY MAOI PHENELZINE
MAOI 苯乙肼抑制快速眼动睡眠的抑郁效应
批准号：
6265188
负责人：
JOHN C GILLIN
金额：
$1.15万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6265188
关键词：
REM sleep adrenocorticotropic hormone antidepressants body temperature circadian rhythms clinical research cortisol dreams drug administration rate /duration drug screening /evaluation electroencephalography emotions human subject human therapy evaluation major depression melatonin memory mental disorder chemotherapy neuroendocrine system phenelzine polygraphy

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英文摘要
To extend knowledge on the regulation and the functions of sleep in health and disease, this study will investigate the effect of the antidepressant phenelzine (Nardil) for at least 5 weeks in patients with major depression. Effect on mood, memory, polygraphic sleep measures, the sleep EEG, circadian phase position (assessed by neuroendocrine measures melatonin, ACTH, cortisol and body temperature) and dream recall will be assessed.
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