TRYPTOPHAN FREE AMINO ACID DRINK EFFECT ON MOOD & SLEEP IN DEPRESSION

不含色氨酸的氨基酸饮料对情绪的影响

• 批准号: 6265150
• 负责人: JOHN C GILLIN
• 金额: $ 1.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265150
• 关键词: alcoholic beverage consumption; aminoacid; antidepressants; blood chemistry; brain metabolism; clinical research; cognition disorders; depression; drug interactions; drug screening /evaluation; emotions; human subject; human therapy evaluation; mental disorder chemotherapy; serotonin; sleep; tryptophan

Test whether a tryptophan free amino acid drink will produce temporary depressive symptoms in euthymic, unmedicated patients who have been treated for depression with group cognitive behavior therapy. The drink reduces plasma tryptophan, reduces brain levels of serotonin, and reverses the antidepressant effects of SSRIs in euthymic depressed patients.

测试色氨酸免费氨基酸饮料是否会产生暂时的抑郁症状，在正常的，未经药物治疗的患者谁已治疗抑郁症与群体认知行为疗法。 这种饮料可以降低血浆色氨酸，降低大脑中5-羟色胺的水平，并逆转SSRIs在正常情绪抑郁患者中的抗抑郁作用。