课题基金 / 基金详情

GRANZYMES OF CYTOTOXIC LYMPHOCYTES

GRANZYMES OF CYTOTOXIC LYMPHOCYTES
细胞毒性淋巴细胞颗粒酶
批准号:
6119173
负责人:
Dorothy Hudig
金额:
$0.54万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-07-01 至 2000-06-30

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中文摘要
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英文摘要
Using the facilities of the Computer Graphics Laboratory, we are working on modelling the substrate binding sites of new granzyme serine proteases, based on the X-ray crystal structure of rat mast cell chymase II, another serine protease. Knowledge of potential substrates will allow them to be synthesized and tested to determine if the granzyme gene products are active enzymes. These proteases are in cytotoxic granules of killer cells and probably play critical roles in killing of virally infected cells and/or in signalling for inflammation.
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Risk of CFS Due to IgG Receptor Genes that Impair ADCC
  • 批准号:
    8876331
  • 项目类别:
  • 资助金额:
    $21.78万
  • 财政年份:
    2015
  • 负责人:
    Dorothy Hudig
  • 依托单位:
FACULTY TRAINING CORE
  • 批准号:
    7610087
  • 项目类别:
  • 资助金额:
    $23.7万
  • 财政年份:
    2007
  • 负责人:
    Dorothy Hudig
  • 依托单位:
FACULTY TRAINING CORE
  • 批准号:
    7381458
  • 项目类别:
  • 资助金额:
    $7.05万
  • 财政年份:
    2006
  • 负责人:
    Dorothy Hudig
  • 依托单位:
GRANZYMES OF CYTOTOXIC LYMPHOCYTES
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