DNA DAMAGE REPAIR ENZYMES ENDONUCLEASE IV & MANGANESE SUPEROXIDE DISMUTASE

DNA 损伤修复酶核酸内切酶 IV

• 批准号: 6119403
• 负责人: YUE GUAN
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119403
• 关键词: genome; proteins

EndoIV is a DNA repair enzyme. Its activity is to catalyze the cleavage of DNA at apurinic sites. Recent reports show that NO and superoxide trigger endoIV expression suggesting that endoIV is important for survival of pathogens. We would like to solve the structure of endoIV to explain the mechanism of this enzyme.

EndoIV是一种DNA修复酶。它的活性是催化 脱氧核糖核酸酶切位点的DNA裂解。最近的报告显示，没有和 超氧化物引发内皮IV的表达提示内皮IV是 对病原体的生存很重要。我们想要解决 EndoIV的结构来解释该酶的机制。