AP ENDONUCLEASE STRUCTURES

AP 核酸内切酶结构

• 批准号: 6119412
• 负责人: YUE GUAN
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119412
• 关键词: biomaterials; genome

EndoIV is a DNA repair enzyme. Its activity is to catalyze the cleavage of DNA at apurinic sites. Recent reports show that nitric oxide and superoxide trigger endoIV expression suggesting that endoIV is important for survival of pathogens. We would like to solve the structure of endoIV to explain the mechanism of this enzyme.

EndoIV是DNA修复酶。 它的活性是催化 DNA在脱嘌呤位点的裂解。 最近的报告显示， 氧化物和超氧化物触发endoIV表达，表明endoIV 对病原体的生存至关重要。 我们想解决 endoIV的结构来解释这种酶的机制。