OXIDATIVE METABOLIC ENZYMES NADH PEROXIDASE, NADH OXIDASE

氧化代谢酶 NADH 过氧化物酶、NADH 氧化酶

• 批准号: 6119404
• 负责人: Joanne I Yeh
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119404
• 关键词: bacteria; proteins

The enteric facultative anaerobes, such as Enterococcus faecalis, are catalase-negative phenotypes and are deficient in heme biosynthesis. Although they also lack respiratory cytochromes, the S. faecalis utilizes oxygen to enhance growth yields. These organisms rely entirely on substrate-level phosphorylation for ATP synthesis and utilizes novel flavoenzymes as oxidoreductases. An understanding of the structural organization of many of the elements contributing to E. faecalis metabolism and regulation would give a clearer picture of their proliferative mechanism. The roles of these flavin-linked enzymes in enterococcal oxidative metabolism and their contribution to their proliferation may yield insight to novel approaches of limiting infection by these organisms.

肠道兼性厌氧菌，如粪肠球菌， 是过氧化氢酶阴性表型，缺乏血红素 生物合成 虽然它们也缺乏呼吸细胞色素，但S。 粪菌利用氧气来提高生长产量。 这些生物体 完全依赖底物水平磷酸化来合成ATP， 利用新的黄素酶作为氧化还原酶。 了解 构成E. 粪便的代谢和调节可以更清楚地了解 其增殖机制。 这些黄素相关的 肠球菌氧化代谢中的酶及其对 它们的扩散可能会产生新的见解， 感染这些生物。