RNA-binding proteins in bacterial virulence and host-pathogen interactions
RNA-binding proteins in bacterial virulence and host-pathogen interactions
批准号:
10659346
负责人:
Melissa Kendall
金额:
$48.57万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-01-14 至 2027-12-31
关键词:
AblationAffectAnimal ModelAttenuatedBacteriaBacteria sigma factor KatF proteinBacterial GenesBiochemicalBiological AssayCarbonCell Culture TechniquesCitrobacter rodentiumColonComplementConsumptionCuesDefectDiffusionDiseaseEnterobacteriaceaeEnvironmentEnzymesEpithelial CellsEpitheliumEscherichia coliEscherichia coli EHECEscherichia coli O157:H7ExhibitsGene ExpressionGene Expression RegulationGeneticGenetic EpistasisGenetic TranscriptionGenomicsGnotobioticGoalsGrowthHemolytic-Uremic SyndromeHemorrhagic colitisHumanHyperplasiaImageIn VitroInfectionInflammatoryIntestinesInvadedKnowledgeLaboratoriesLifeLocationMetabolicMetabolismMolecularMolecular TargetMucous MembraneMusMutationNitrogenNutrientOxidation-ReductionOxygenPathogenesisPhagocytesPhenotypePhysiologyPlayPost-Transcriptional RegulationRNA HelicaseRNA StabilityRNA metabolismRNA-Binding ProteinsRegulationRespirationRoleShockSignal TransductionStructureTechniquesTemperatureTestingThinkingTissuesTranscriptTranslationsType III Secretion System PathwayVirulenceWorkbacterial geneticscell motilitycold temperaturecostdesignexperimental studyfitnessfunctional outcomesgut colonizationhelicaseimprovedin vivomembermodel organismmouse modelmutantnovel therapeuticspathogenpathogenic bacteriapharmacologicresponsespatiotemporaltraittranscription terminationtranscriptomicsvirulence gene
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
The ability of bacteria to rapidly sense and respond to changes in the environment is fundamental
to colonization. Post-transcriptional regulation is emerging as an important strategy that promotes
efficient and precise control of bacterial virulence, and thus plays a central role in pathogenesis.
Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a bacterial pathogen that colonizes the
human colon and causes severe hemorrhagic colitis and hemolytic uremic syndrome (HUS), which
can be fatal. EHEC is able to efficiently acquire nutrients and coordinate expression of traits that
promote intestinal colonization, suggesting that EHEC has evolved mechanisms to spatiotemporally
control virulence gene expression to occur within appropriate host niches. RNA binding proteins play
important roles in bacterial gene expression by modulating transcription termination, RNA stability,
and translation; however, the targets and molecular mechanisms of most RNA binding proteins and
the corresponding impact on bacterial virulence and host interactions are poorly resolved. The
proposed work will elucidate the regulatory mechanisms of RNA binding proteins and importance to
fitness within the intestine, as well as examine how these RNA binding proteins are activated within
transcriptional networks and in response to host cues.
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会议论文
sRNAs in EHEC virulence
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批准号:10408173
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项目类别:
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资助金额:$19.71万
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财政年份:2021
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负责人:Melissa Kendall
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依托单位:
sRNAs in EHEC virulence
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批准号:10286819
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项目类别:
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资助金额:$23.75万
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财政年份:2021
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负责人:Melissa Kendall
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依托单位:
RNA helicases in bacterial pathogenesis
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批准号:10217792
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项目类别:
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资助金额:$23.74万
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财政年份:2021
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负责人:Melissa Kendall
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依托单位:
RNA helicases in bacterial pathogenesis
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批准号:10360660
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资助金额:$19.7万
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财政年份:2021
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Roles of Archaea in infectious disease
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批准号:9808070
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资助金额:$7.15万
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财政年份:2019
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负责人:Melissa Kendall
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依托单位:
Ethanolamine Signaling in Virulence Gene Regulation and Host/Microbial Interactions
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批准号:9065488
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项目类别:
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资助金额:$38.89万
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财政年份:2015
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负责人:Melissa Kendall
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依托单位:
Ethanolamine Signaling in Virulence Gene Regulation and Host/Microbial Interactions
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批准号:9262867
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项目类别:
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资助金额:$38.89万
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财政年份:2015
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负责人:Melissa Kendall
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依托单位:
Regulation of EHEC virulence genes by QseA and small RNA molecules
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批准号:7545685
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项目类别:
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资助金额:$4.96万
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财政年份:2008
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负责人:Melissa Kendall
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依托单位:
Regulation of EHEC virulence genes by QseA and small RNA molecules
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批准号:7807910
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项目类别:
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资助金额:$5.17万
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财政年份:2008
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负责人:Melissa Kendall
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依托单位:
海外基金