TUMOR SUPPRESSORS & CELL CYCLE CONTROL

细胞周期和生长对正常的人类健康至关重要。肿瘤 抑制子控制这些功能和突变或改变 这些抑制分子可以与不受控制的 肿瘤的生长。我们正在研究视网膜母细胞瘤蛋白和一种 与Rb结合的新蛋白RIZ本身可能是一种肿瘤抑制因子。 Rb通过一个称为口袋的区域与细胞蛋白质结合 由两个区域(A和B)组成的域，由灵活的 细分市场。人类肿瘤中的大多数突变都映射到“口袋”结构域。 在我们的口袋领域已经生产出了小晶体 拉布拉多。以前，A区的结构是口袋 域已确定，但仅此数据段的功能不是 为人所知。我们的目标是解决完整的“口袋”域的结构 并将研究扩展到与RIZ的结合相互作用。

Cell cycle and growth are critical for normal human health. Tumor suppressors control these functions and mutations or alterations of these suppressor molecules can be associated with the uncontrolled growth of tumors. We are studying the retinoblastoma protein and a new protein RIZ that binds to Rb and may itself be a tumor suppressor. Rb binds to cellular proteins through a region known as the pocket domain that consists of two regions (A and B) connected by a flexible segment. Most mutations in human tumors map to the "pocket" domain. Small crystals have already been produced of the pocket domain in our laboaratory. Previously, the structure of the A region of the pocket domain was determined, but the function of this segment alone is not known. Our goal is to solve the structure of the full "pocket" domain and to extend the studies to binding interactions with RIZ.