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DIFFRACTION FROM CRYSTALS OF MULTIMODULE FIBRONECTIN CELL ADHESION FRAGMENTS

DIFFRACTION FROM CRYSTALS OF MULTIMODULE FIBRONECTIN CELL ADHESION FRAGMENTS
多模块纤连蛋白细胞粘附片段晶体的衍射
批准号：
6586620
负责人：
KATHRYN R. ELY
金额：
$14.32万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-03-01 至 2003-02-28
来源：
https://reporter.nih.gov/project-details/6586620
关键词：
bioimaging /biomedical imaging biomaterials biomedical resource proteins radiography structural biology

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英文摘要
Recognition of extracellular ligands by cell surface receptors (integrins) is critical for cell adhesion, migration and tracking and perhaps the metastatic spread of tumor cells. This recognition is mediated in part by an arginine-glycine-aspartic acid sequence in extracellular proteins. We have recently cloned and expressed larger multimodule fragments that each contain the module FN 11110. We have crystallized three of these fragments. These fragments are important structural candidates to reveal the 3D organization of the RGD site and synergistic sites in adjacent domains that are required for integrin recognition and adhesive function of the molecule. Synchrotron radiation is needed to collect heavy atom data from these small crystals.
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TRAF MOLECULES IN CELL SIGNALING
  • 批准号：
    7954191
  • 项目类别：
  • 资助金额：
    $0.02万
  • 财政年份：
    2009
  • 负责人：
    KATHRYN R. ELY
  • 依托单位：
    STANFORD UNIVERSITY
SOLUTION STRUCTURE OF SERINE-RICH DOMAIN FROM CRK-ASSOCIATED SUBSTRATE
SOLUTION STRUCTURE OF SERINE-RICH DOMAIN FROM CRK-ASSOCIATED SUBSTRATE
TRAF MOLECULES IN CELL SIGNALING
  • 批准号：
    7721795
  • 项目类别：
  • 资助金额：
    $0.02万
  • 财政年份：
    2008
  • 负责人：
    KATHRYN R. ELY
  • 依托单位：
    STANFORD UNIVERSITY
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