PART I: ANALYSIS OF PROTEIN TYROSINE SULFATION

第一部分：蛋白质酪氨酸硫酸化分析

• 批准号: 6220987
• 负责人: GRACE L ROSENQUIST
• 金额: $ 0.28万
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220987
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biomedical resource; cardiovascular system; statistics /biometry; technology /technique

In the United States alone, there are 400,000 sudden cardiac deaths annually resulting from cardiac electrical dysfunction. The availability of a non-invasive means of mapping spatially distributed cardiac electrical activity will play a significant role in predicting cardiac dysfunction and guiding therapeutic techniques. This project aims at greatly enhancing spatial resolution for non-invasive mapping of cardiac electrical activity currently achieved. We have developed a novel imaging technique which has been demonstrated to provide high resolution in mapping cardiac electrical activity. We propose to systematically investigate the relationship between distributed cardiac electrical activity and body surface Laplacian maps when realistic torso geometry is considered. The intensive computation requires the use of supercomputing facilities. We hope this starter grant, if approved, will enable us to explore the feasibility of using the PSC Supercomputer to achieve the aforementioned scientific goals, and help make this important imaging technology available to patients suffered from risks of sudden cardiac deaths. No other active or pending supercomputing proposals for this project.

仅在美国，就有40万例心脏骤停