MICROSCOPIC NMR IMAGING

显微核磁共振成像

• 批准号: 6122337
• 负责人: PAUL C LAUTERBUR
• 金额: $ 17.02万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-10 至 2000-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122337
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biological products; biomedical equipment development; biomedical resource; computers; human tissue; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; statistics /biometry; technology /technique

NMR microscopy has been developed for in vitro and in vivo applications at cellular resolution. Various radio frequency and gradient coil geometries have been developed to maximize signal-to-noise ratio and spatial resolution depending on sample size and region of interest. Theoretical and experimental performance of these coils are in good agreement. Experimental confirmation of the predicted restricted diffusion effects is underway using gas and liquid phase samples. Efficient data sampling methods and image processing techniques are being developed to reduce the data acquisition time. New methods of NMR microscopy are being developed using diffusion to simultaneously increase sensitivity and resolution. Methods have been developed and theoretical results obtained that provide a more complete basis for interpreting microscopic NMR images in the presence and absence of restricted diffusion and of magnetic molecules and particles that alter relaxation times or local magnetic fields. The theory of diffusion-enhanced microscopy has been developed for one-, two-, and three-dimensional systems.

核磁共振显微技术已经发展到体外和体内。 蜂窝分辨率的应用。各种无线电频率和 梯度线圈的几何形状已经开发成最大限度地 信噪比和空间分辨率取决于样本大小 和感兴趣的区域。它的理论和实验性能 这些线圈吻合得很好。实验证实了这一点。 预测的限制扩散效应正在使用气体和 液体样品。高效的数据采集方法和图像 正在开发处理技术来减少数据 获取时间。核磁共振显微镜的新方法正在开发中 利用扩散同时提高灵敏度和分辨率。 已经发展了一些方法，并获得了理论结果 为解释显微核磁共振图像提供了更完整的基础 在存在和不存在限制扩散和磁场的情况下 改变弛豫时间或局部磁性的分子和粒子 菲尔兹。扩散增强显微镜的理论已经被 为一维、二维和三维系统开发的。