SIMULATION OF DIFFUSIONALLY ENHANCED NMR MICROSCOPY

在 NMR 显微镜领域，通过以下方式获取物体图像 小于几微米的特征是一个非常重要的目标。 然而，这样的目标是由细胞生物学问题强烈激发的 及其许多相关领域以及材料问题 科学。 敏感性不足是罪魁祸首，许多 研究人员设计了创造性的方法来解决这个问题。 不足 分辨率也是罪魁祸首；对于半流体系统，平移 分隔几何形状内的扩散通常会导致 与运动相关的图像失真。 扩散法 信号强度和分辨率（DESIRE）的增强 为回应这些问题而推出。 欲望耦合饱和 旋转“稀有”探测区域的种群，初始 通过空间扩散形成不饱和的“丰富”储层。 这个 由群体操纵的核磁共振显微镜是前所未有的 在现有的文献中。 模拟将提供深入了解 许多无法直接观察到的特征性物理事件 并激发DESIRE的持续发展。

In the field of NMR microscopy, obtaining images of objects with features smaller than several microns is a highly nontrivial goal. Such a goal, however, is acutely motivated by problems of cell biology and its many associated fields as well as problems from materials science. Inadequate sensitivity is a primary culprit and many investigators have devised creative methods to address it. Inadequate resolution is also a culprit; for semi-fluid systems, translational diffusion within compartmentalized geometries typically leads to motion-dependent distortions to images. The method of Diffusional Enhancement of Signal Intensity and REsolution, or DESIRE, has been introduced to respond to these issues. DESIRE couples the saturated spin population of a 'rare' probing region with an initially unsaturated 'abundant' reservoir by diffusion through space. This kind of NMR microscopy by manipulation by populations is unprecedented in the existing literature. Simulations will provide insight into many characteristic physical events which cannot be directly observed and stimulate the continuing development of DESIRE.