SIMULATION OF DIFFUSIONALLY ENHANCED NMR MICROSCOPY

扩散增强核磁共振显微镜的模拟

• 批准号: 6411697
• 负责人: PAUL C LAUTERBUR
• 金额: $ 1.29万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6411697
• 关键词: biomedical resource; computers; nuclear magnetic resonance spectroscopy; technology /technique

In the field of NMR microscopy, obtaining images of objects with features smaller than several microns is a highly nontrivial goal. Such a goal, however, is acutely motivated by problems of cell biology and its many associated fields as well as problems from materials science. Inadequate sensitivity is a primary culprit and many investigators have devised creative methods to address it. Inadequate resolution is also a culprit; for semi-fluid systems, translational diffusion within compartmentalized geometries typically leads to motion-dependent distortions to images. The method of Diffusional Enhancement of Signal Intensity and REsolution, or DESIRE, has been introduced to respond to these issues. DESIRE couples the saturated spin population of a 'rare' probing region with an initially unsaturated 'abundant' reservoir by diffusion through space. This kind of NMR microscopy by manipulation by populations is unprecedented in the existing literature. Simulations will provide insight into many characteristic physical events which cannot be directly observed and stimulate the continuing development of DESIRE.

在NMR显微镜领域中，获得物体的图像， 小于几微米的特征是非常重要的目标。 然而，这样一个目标是由细胞生物学问题强烈激发的 以及与之相关的许多领域， 科学 灵敏度不足是罪魁祸首，许多 调查人员设计了创造性的方法来解决这个问题。 分辨率也是罪魁祸首;对于半流体系统，平移 在分隔的几何形状内的扩散通常导致 图像的运动相关失真。 扩散法 增强信号强度和REsolution，或RES1RE，已经被 提出来回应这些问题。 将饱和的 具有初始自旋态的"稀有"探测区的自旋布居 通过空间扩散形成的非饱和"丰富"储层。 这 一种由群体操纵的核磁共振显微镜是前所未有的 在现有的文献中。 模拟将提供洞察力， 许多无法直接观察到的特征性物理事件 并促进可持续发展。