SIMULATION OF DIFFUSIONALLY ENHANCED NMR MICROSCOPY

在核磁共振显微镜领域，获得物体的图像 小于几微米的特征是一个非常重要的目标。 然而，这样的目标受到细胞生物学问题的强烈推动。 以及它的许多相关领域以及来自材料的问题 科学。敏感度不足是罪魁祸首，许多人 调查人员已经想出了创造性的方法来解决这个问题。不足之处 分辨率也是罪魁祸首；对于半流体系统，平移 在划分的几何图形内的扩散通常会导致 图像的运动相关失真。扩散法 信号强度和分辨率的增强，或期望的 为应对这些问题而推出的。欲望将饱和的人结合起来 一种“稀有”探测区的自旋布居 非饱和的“丰富”水库通过在空间中扩散。这 通过种群操纵的核磁共振显微镜是史无前例的 在现有的文献中。模拟将提供对 许多不能直接观察到的特征物理事件 并刺激欲望的持续发展。

In the field of NMR microscopy, obtaining images of objects with features smaller than several microns is a highly nontrivial goal. Such a goal, however, is acutely motivated by problems of cell biology and its many associated fields as well as problems from materials science. Inadequate sensitivity is a primary culprit and many investigators have devised creative methods to address it. Inadequate resolution is also a culprit; for semi-fluid systems, translational diffusion within compartmentalized geometries typically leads to motion-dependent distortions to images. The method of Diffusional Enhancement of Signal Intensity and REsolution, or DESIRE, has been introduced to respond to these issues. DESIRE couples the saturated spin population of a 'rare' probing region with an initially unsaturated 'abundant' reservoir by diffusion through space. This kind of NMR microscopy by manipulation by populations is unprecedented in the existing literature. Simulations will provide insight into many characteristic physical events which cannot be directly observed and stimulate the continuing development of DESIRE.