Quantifying Artificial Pancreas-related Changes in Diabetic Neuropathy

点击翻译按钮获取中文摘要

A complication of diabetes mellitus is damage to nerves called neuropathy which can lead to foot ulcers, infections and amputations. Patients with neuropathy may also experience pain, which can be difficult to control and the medications are limited by side effects. Neuropathy also affect the nerve supplying the heart and lungs (cardiac autonomic neuropathy (CAN)) which can be associated with premature death. Despite this there are no approved treatments to reverse the progression of neuropathy and management is focused on controlling blood glucose and other metabolic factors to prevent neuropathy and its symptoms from getting worse.Patients with type 1 diabetes are prescribed multiple daily injections (MDI) of insulin to manage their glucose control. However, insulin pump therapy and, more recently, automated insulin delivery (AID) or the Artificial Pancreas can be used as the insulin delivery method for patients with type 1 diabetes mellitus. Manchester Diabetes, Endocrinology and Metabolism Centre is the first adult diabetes centre in Europe to pioneer and use a commercially-approved artificial pancreas in clinical practice. Insulin pump therapy and the automatic pancreas have the advantage of being able to provide insulin at variabledoses, which is closer to the natural process occurring within an individual without diabetes. Both are currently considered to be the most physiological method of insulin delivery and have been shown to improve glycaemic control, quality of life (QOL) and reduce the risk of hypoglycaemia (low blood glucose level). We have previously shown in a small group of people that use of an insulin pump therapy may improve symptoms of painful neuropathy via a more stable glucose profile. The peaks and drops in insulin may make neuropathy worse.In the observational study we aim to investigate the use of the artificial pancreas and insulin pump therapy in their effect on neuropathy. We will use a variety of assessments and symptom questionnaires to assess structural and functional neuropathy status. We hypothesise that those patients receiving the newer technologies will demonstrate an improvement in symptoms and nerve regeneration. I will analyse data from a randomised control trial comparing the artificial pancreas to a sensor-augmented closed loop system. The purpose of this is to evaluate the impact of these on cardiac autonomic neuropathy where I believe that the artificial pancreas will be able to offer a better delivery of glucose and thus have a positive impact on CAN.This finding would have a significant impact for patients by providing evidence that patients with neuropathy would benefit from these devices. As these are devices that are already available on the NHS to patients satisfying specific criteria this study aims to show benefit in a wider cohort of patients which can be implemented immediately in clinical practice.