SIMULATION OF WALL MOTION ON FLOW IN ELASTIC MODEL OF CURVED ARTERY

本实验室开展的项目主要围绕以下主题展开 T细胞受体与信号的结构/功能相关性 效应器T细胞的转导通路。几个V*基因已经被 标识，用于对定义的 同种异体的特性。表达a基因的肿瘤特异性T细胞系 已使用特定T细胞受体来识别肿瘤特异性 抗原。这已经导致了一种粘蛋白分子的鉴定 (人粘蛋白MUC-1)由导管上皮细胞表达，并由 糖基化改变的肿瘤能够刺激T细胞 豁免权。粘蛋白的结构用核磁共振和核磁共振表征。 圆二色法以选择最优疫苗或 乳腺癌和胰腺癌的免疫治疗抗原。这个 我们在这两个系统中研究的效应T细胞对抗原有反应 通过激活几个细胞内信号通路来刺激。 我们特别感兴趣的是PKC途径作为一种调控手段 抑制和控制T细胞的激活。

The projects pursued in this laboratory center on the topics of structure/function correlation of T cell receptors, and signal transduction pathways in effector T cells. Several V* genes have been identified which are used to carry out recognition of defined allospecificities. Tumor specific T cell lines which express a particular T cell receptor have been use to identify tumor specific antigens. This has already led to identification of a mucin molecule (human mucin muc-1) expressed by ductal epithelial cells, and by tumors in an altered glycosylation form capable of stimulating T cell immunity. The structure of mucin is being characterized by NMR and circular dichroism in order to select the optimal vaccine or immunotherapeutic antigen for breast and pancreatic cancer. The effector T cells which we study in both systems respond to antigen stimulation by activating several intracellular signaling pathways. We are especially interested in the PKC pathway as a mean of pr omoting and controlling T cell activation.