Genomic Epidemiology to underpin One Health surveillance for rabies

基因组流行病学支持 One Health 狂犬病监测

基本信息

  • 批准号:
    MR/X002047/1
  • 负责人:
  • 金额:
    $ 83.4万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    未结题

项目摘要

Genomic surveillance, i.e. using a pathogen's genetic blueprint to track it's spread in response to control measures, has become a key tool in contemporary disease management. This approach can now be deployed almost anywhere and conducted in near real-time to inform rapid and targeted interventions. Yet genomic surveillance is typically applied to emerging diseases with pandemic potential (e.g. SARS-COV-2) in high-income countries. I propose repurposing genomic surveillance for endemic zoonoses, diseases that spread from animals to people, such as rabies, that inflict a major preventable disease burden in many low- and middle-income countries. Such an approach would simultaneously improve surveillance for emerging infectious diseases through locally relevant capacity strengthening and provide the means to develop cutting-edge methodologies and capacities in "pandemic peacetime", whilst generating visible, tangible impacts on public health. My proposal focuses on developing and optimising an accessible toolkit for generating and interpreting rabies virus genetic sequence data, supporting the global strategy to achieve zero human rabies deaths from rabies spread by domestic dogs by 2030. Genomic surveillance can play a key role in resolving complex transmission dynamics, detecting introductions and identifying their sources. This epidemiological understanding is important for both designing and evaluating national rabies elimination programmes, as they are increasingly rolled out. The proposed work encapsulates novel laboratory techniques to generate sequences in resource poor settings, and contemporary methods for analyzing these data to track rabies spread and persistence, both locally within communities and longer-range movement across countries and regions. I will deploy this toolbox through my extensive international collaborations across Africa, Asia and Latin America to address specific questions to support rabies elimination programmes in practice, building local capacity and expertise for routine in-country genomic surveillance.
基因组监测,即使用病原体的遗传蓝图来跟踪其传播以应对控制措施,已成为当代疾病管理的关键工具。这种方法现在几乎可以在任何地方部署,并以近乎实时的方式进行,以提供快速和有针对性的干预措施。然而,基因组监测通常适用于高收入国家具有大流行潜力的新出现疾病(如SARS-COV-2)。我建议将基因组监测重新用于地方性人畜共患病,即从动物传播到人的疾病,如狂犬病,这些疾病在许多低收入和中等收入国家造成了重大的可预防疾病负担。这种方法将同时通过加强当地相关能力来改善对新出现的传染病的监测,并提供在“流行病和平时期”发展尖端方法和能力的手段,同时对公共卫生产生明显、切实的影响。我的建议侧重于开发和优化一个可访问的工具包,用于生成和解释狂犬病病毒基因序列数据,支持到2030年实现由家犬传播的狂犬病造成的人类狂犬病死亡为零的全球战略。基因组监测可以在解决复杂的传播动态、检测传入和确定其来源方面发挥关键作用。这种流行病学的理解对于设计和评估国家狂犬病消除计划非常重要,因为它们越来越多地推出。拟议的工作包括在资源贫乏的环境中生成序列的新型实验室技术,以及分析这些数据以跟踪狂犬病传播和持续性的当代方法,包括社区内的局部和国家和地区之间的长距离移动。我将通过我在非洲、亚洲和拉丁美洲的广泛国际合作部署这一工具箱,以解决具体问题,支持在实践中消除狂犬病的计划,建设当地常规国内基因组监测的能力和专业知识。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus
  • DOI:
    10.1101/2023.09.04.556169
  • 发表时间:
    2023-09
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Rowan Durrant;C. Cobbold;K. Brunker;Kathryn Campbell;J. Dushoff;E. A. Ferguson;Gurdeep Jaswant;A. Lugelo;K. Lushasi;Lwitiko Sikana;Katie Hampson
  • 通讯作者:
    Rowan Durrant;C. Cobbold;K. Brunker;Kathryn Campbell;J. Dushoff;E. A. Ferguson;Gurdeep Jaswant;A. Lugelo;K. Lushasi;Lwitiko Sikana;Katie Hampson
Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology
  • DOI:
    10.3791/65414
  • 发表时间:
    2023-08-01
  • 期刊:
  • 影响因子:
    1.2
  • 作者:
    Bautista,Criselda;Jaswant,Gurdeep;Brunker,Kirstyn
  • 通讯作者:
    Brunker,Kirstyn
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Kirstyn Brunker其他文献

From emergence to endemicity of highly pathogenic H5 avian influenza viruses in Taiwan
从高致病性 H5 禽流感病毒在台湾的出现到地方流行
  • DOI:
    10.1038/s41467-024-53816-y
  • 发表时间:
    2024-10-29
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Yao-Tsun Li;Hui-Ying Ko;Joseph Hughes;Ming-Tsan Liu;Yi-Ling Lin;Katie Hampson;Kirstyn Brunker
  • 通讯作者:
    Kirstyn Brunker
Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines
结合基因组学和流行病学来调查菲律宾罗姆布隆省一起人畜共患狂犬病疫情
  • DOI:
    10.1038/s41467-024-54255-5
  • 发表时间:
    2024-12-30
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Mirava Yuson;Criselda T. Bautista;Eleanor M. Rees;Carlijn Bogaardt;Van Denn D. Cruz;Rowan Durrant;Anna Formstone;Daria L. Manalo;Duane R. Manzanilla;Mikolaj Kundergorski;Leilanie Nacion;Hannaniah Aloyon;Jude Karlo Bolivar;Jeromir Bondoc;Christina Cobbold;Efraim Panganiban;Shynie Vee. M. Telmo;Jobin Maestro;Mary Elizabeth G. Miranda;Nai Rui Chng;Kirstyn Brunker;Katie Hampson
  • 通讯作者:
    Katie Hampson

Kirstyn Brunker的其他文献

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{{ truncateString('Kirstyn Brunker', 18)}}的其他基金

Implementing genomic surveillance to support SARS-CoV-2 control and mitigation strategies in the Philippines
在菲律宾实施基因组监测以支持 SARS-CoV-2 控制和缓解战略
  • 批准号:
    MR/V035444/1
  • 财政年份:
    2020
  • 资助金额:
    $ 83.4万
  • 项目类别:
    Research Grant

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