DEVELOPMENT OF FIELD FREQUENCY LOCKS FOR L BAND SPECTROMETERS
L波段光谱仪场频锁的研制
基本信息
- 批准号:6206509
- 负责人:
- 金额:$ 0.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-01 至 2000-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Despite the wealth of knowledge about the chemistry of nitric
oxide (NO), there is considerable uncertainty regarding the reactions
of NO in vivo. One goal of this research is to characterize the
interaction of nitric oxide with protein-bound iron, typically with
thiol ligands. A second goal of the research is to use
dithiocarbamates as in vivo spin traps for NO in mice, allowing the
real-time detection of NO through L-band EPR spectroscopy and the ex
vivo analysis of individual organs through X-band spectroscopy. This
technique has been successful for detecting NO production in mouse
septic shock models, utilizing diethyl dithiocarbamate (DETC) and
N-methyl-D-glucamine dithiocarbamate injected along with iron(II)
sulfate and sodium citrate. The EPR signal observed is characteristic
of a mononitrosyl iron complex; in L-band spectroscopy it consists of
an essentially symmetrical triplet with splitting of approximately
12.8 Gauss due to the nitrogen. In the current trials, the signal
produced by the Fe-DETC-NO complex has a greater intensity, likely due
to its greater lipophilicity and ability to concentrate in cell
membranes. Future work will involve testing a variety of other
dithiocarbamates, including the sarcosine, pyrrolidine, and proline
derivatives, in order to maximize the spectrum from trapped NO in the
liver, kidney, brain, spinal cord, and in circulation.
尽管我们对氮的化学性质有丰富的了解
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ILDAR SALIKOV其他文献
ILDAR SALIKOV的其他文献
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{{ truncateString('ILDAR SALIKOV', 18)}}的其他基金
DEVELOPMENT OF FIELD FREQUENCY LOCKS FOR L BAND SPECTROMETERS
L波段光谱仪场频锁的研制
- 批准号:
6353183 - 财政年份:2000
- 资助金额:
$ 0.61万 - 项目类别:
FIELD FREQUENCY LOCK FOR AN L BAND SPECTROMETER W/ PERMANENT MAGNET
带永磁体的 L 波段光谱仪的场频锁定
- 批准号:
6123397 - 财政年份:1998
- 资助金额:
$ 0.61万 - 项目类别:
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