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BIOLOGICAL MARKERS FOR PRIMARY DEMENTIA IN ELDERLY

BIOLOGICAL MARKERS FOR PRIMARY DEMENTIA IN ELDERLY
老年人原发性痴呆的生物标志物
批准号：
6221115
负责人：
GEORGE S ZUBENKO
金额：
$0.13万
依托单位：
MELLON PITTS CORPORATION (MPC CORP)
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-08-01 至 2000-07-31
来源：
https://reporter.nih.gov/project-details/6221115
关键词：
Chordata Mammalia biomedical resource cardiovascular system connective tissue enzymes hematology hormones intestines proteins stomach

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中文摘要
翻译
本课题的研究重点是对大鼠肝细胞的调控和功能进行研究， 脂多糖结合蛋白（LBP）。 LBP是血清蛋白 由肝脏产生，与细菌形成高亲和力结合， 脂多糖（LPS）和这种复合物一起显着 通过巨噬细胞上调细胞因子如TNF的产生。 认为LBP在脓毒症的发病机制中起重要作用 冲击. 本实验室最近克隆并测序了一个全长cDNA 老鼠的LBP 我们计划进一步克隆大鼠启动子 对于LBP
英文摘要
The focus of our research is on the regulation and function of rat lipopolysaccharide binding protein (LBP). LBP is a serum protein produced by the liver which forms a high affinity bond to bacterial lipopolysaccharides (LPS) and together this complex significantly upregulates the production of cytokines such as TNF by macrophages. LBP is felt to play significant role in the pathogenesis of septic shock. Our lab has recently cloned and sequenced a full length cDNA for rat LBP. We plan to proceed further and clone the rat promoter for LBP.
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