Genetics, pathobiology and treatment of age-related hearing loss

年龄相关性听力损失的遗传学、病理学和治疗

• 批准号: MR/X004597/1
• 负责人: Michael Bowl
• 金额: $ 129.29万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX004597%2F1
• 关键词: Genetics; pathobiology; treatment; age; related

The overarching rationale for my research programme is that the integration of human and mouse approaches will lead to a more profound understanding of the genetics underlying hearing loss, which for age-related hearing loss (ARHL) in particular is currently very limited. Moreover, the study and comparison of mouse models will provide essential information regarding the progressive molecular and cellular processes occurring in the mammalian cochlea, something that cannot be determined in humans. Ultimately, this increased understanding will lay the foundation necessary for developing therapeutic interventions, such as gene, regeneration or small molecule therapies.

我的研究计划的主要理由是，人类和老鼠方法的整合将导致对听力损失背后的遗传学有更深刻的理解，这一点目前对年龄相关性听力损失(ARHL)来说是非常有限的。此外，对小鼠模型的研究和比较将提供关于哺乳动物耳蜗中发生的进展的分子和细胞过程的基本信息，这在人类身上是无法确定的。最终，这种理解的增加将为开发治疗干预措施奠定必要的基础，例如基因、再生或小分子疗法。

项目成果

Investigating audible and ultrasonic noise in modern animal facilities.

研究现代动物设施中的声音和超声波噪声。

• DOI: 10.12688/f1000research.111170.1
• 发表时间: 2022
• 期刊: F1000Research

Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia.

肌动蛋白15在机械感觉立体胶质中对肌动蛋白动力学的可调结构基础。

• DOI: 10.1126/sciadv.abl4733
• 发表时间: 2022-07-22
• 期刊: Science advances
• 影响因子: 13.6

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.

神经塑料与钙粘蛋白23的遗传相互作用，编码的同工型NP55足以足以完成耳蜗功能和听力。

• DOI: 10.1371/journal.pgen.1009937
• 发表时间: 2022-01
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Newton S;Kong F;Carlton AJ;Aguilar C;Parker A;Codner GF;Teboul L;Wells S;Brown SDM;Marcotti W;Bowl MR
• 通讯作者: Bowl MR