Understanding the role of bacterial adhesion during Staphylococcus aureus skin colonisation in atopic dermatitis

了解细菌粘附在金黄色葡萄球菌皮肤定植过程中在特应性皮炎中的作用

• 批准号: MR/X009319/1
• 负责人: Joan Geoghegan
• 金额: $ 51.59万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX009319%2F1
• 关键词: Understanding; role; bacterial; adhesion; during

Atopic dermatitis (AD, also commonly called eczema), is the most common chronic skin disorder in children. The bacterium Staphylococcus aureus sticks to dead flattened cells on the surface of skin known as corneocytes, increasing inflammation and worsening AD symptoms. Our research aims to uncover the complete set of bacterial proteins that support the attachment of S. aureus to corneocytes and to identify the host factors they interact with. This project also aims to provide an understanding of how other related bacteria that exist on the skin as commensals (coagulase negative staphylococci) regulate the adherence of S. aureus to the skin. The knowledge gained from this project will open up the possibility of targeting S. aureus-corneocyte interactions as a strategy to specifically interfere with S. aureus adhesion and prevent or eliminate colonisation in AD patients.

特应性皮炎（AD，又称湿疹）是儿童最常见的慢性皮肤病。金黄色葡萄球菌附着在皮肤表面被称为角质层的扁平死亡细胞上，增加炎症并恶化阿尔茨海默病症状。我们的研究旨在揭示一整套支持金黄色葡萄球菌附着于角质细胞的细菌蛋白，并确定它们与宿主因子相互作用。该项目还旨在了解作为共生体存在于皮肤上的其他相关细菌（凝固酶阴性葡萄球菌）如何调节金黄色葡萄球菌对皮肤的粘附。从该项目中获得的知识将开辟以金黄色葡萄球菌-角质细胞相互作用为目标的可能性，作为特异性干扰金黄色葡萄球菌粘附并预防或消除AD患者定植的策略。