FUNCTIONAL ANALYSIS OF THE IG LOCUS CONTROL REGION
IG 基因座控制区的功能分析
基本信息
- 批准号:6149884
- 负责人:
- 金额:$ 28.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-02-01 至 2003-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: Transcriptional regulation in vivo involves both local and
long-range interactions that occur within specialized "open" chromosomal
domains. Composite DNA elements which induce the formation of these
structures are termed Locus Control Regions (LCRs). Transcriptional
enhancers within LCRs initiate local changes in otherwise condensed
higher-order chromatin structures, which can be propagated to more distal
regions in the presence of nuclear matrix attachment regions (MARs). These
LCR-induced changes in chromatin accessibility are required for functional
interactions between widel separated enhancers and promoters.
These effects have been described in transgenic mouse experiments and are,
consequently difficult to study at the mechanistic level. To this end, the
PI has recently developed a transfection method which reveals the functional
contribution of each of the subelements within a well described LCR. This
assa will expedite the identification of novel DNA regulatory elements and
trans-acting factors that participate in long-range remodeling of chromatin.
The immunoglobulin mu LCR consists of a classical enhancer element and
flankin MARs. To understand how these elements collaborate to remodel large
chromatin domains and permit interactions between the enhancer and distal
promoters, the PI proposes the following 3 specific aims: 1) To identify
the specific MAR sequences necessary for LCR function, 2) To identify
MAR-binding protein factors which are a functional component of the active
mu LCR, and 3) To investigate the mechanism by which the MARs and
MAR-binding factors govern distal enhancer function and chromatin
remodeling.
LCRs, and the mechanisms by which they govern gene expression, are likely to
b used at many, if not all, developmentally regulated loci. These studies
will yield novel insights into LCR structure and function which should
expand opportunities for regulated and targeted gene therapy.
描述:体内的转录调控包括局部和
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM C FORRESTER其他文献
WILLIAM C FORRESTER的其他文献
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{{ truncateString('WILLIAM C FORRESTER', 18)}}的其他基金
FUNCTIONAL ANALYSIS OF THE IG LOCUS CONTROL REGION
IG 基因座控制区的功能分析
- 批准号:
6497101 - 财政年份:1998
- 资助金额:
$ 28.1万 - 项目类别:
FUNCTIONAL ANALYSIS OF THE IG LOCUS CONTROL REGION
IG 基因座控制区的功能分析
- 批准号:
6349857 - 财政年份:1998
- 资助金额:
$ 28.1万 - 项目类别:
FUNCTIONAL ANALYSIS OF THE IG LOCUS CONTROL REGION
IG 基因座控制区的功能分析
- 批准号:
2599457 - 财政年份:1998
- 资助金额:
$ 28.1万 - 项目类别:
FUNCTIONAL ANALYSIS OF THE IG LOCUS CONTROL REGION
IG 基因座控制区的功能分析
- 批准号:
2871577 - 财政年份:1998
- 资助金额:
$ 28.1万 - 项目类别:
REGULATION OF THE MURINE HEAVY CHAIN IMMUNOGLOBULIN GENE
鼠重链免疫球蛋白基因的调控
- 批准号:
2084644 - 财政年份:1992
- 资助金额:
$ 28.1万 - 项目类别:
REGULATION OF THE MURINE HEAVY CHAIN IMMUNOGLOBULIN GENE
鼠重链免疫球蛋白基因的调控
- 批准号:
3034299 - 财政年份:1991
- 资助金额:
$ 28.1万 - 项目类别:
REGULATION OF THE MURINE HEAVY CHAIN IMMUNOGLOBULIN GENE
鼠重链免疫球蛋白基因的调控
- 批准号:
3034300 - 财政年份:1991
- 资助金额:
$ 28.1万 - 项目类别:
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