JUVENILE ONSET OCD AS A MEANINGFUL DEVELOPMENT SUBTYPE

青少年发作的强迫症是一种有意义的发展亚型

• 批准号: 6185592
• 负责人: DANIEL A GELLER
• 金额: $ 16.29万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185592
• 关键词: Tourette's syndrome; adolescence (12-20); adult human (21+); age difference; attention deficit disorder; body physical characteristic; clinical research; comorbidity; disease /disorder classification; disease /disorder etiology; disease /disorder onset; family genetics; genetic susceptibility; human puberty; human subject; interview; longitudinal human study; mental disorder diagnosis; neuropsychology; obsessive compulsive disorder; phenotype; prognosis; psychological tests; questionnaires

This application represents an integrated plan of research and training which will allow the Candidate to acquire the necessary skills to become independent as a clinical investigator. The Candidate has demonstrated a commitment towards the pursuit of clinical excellence and original research in the area of Obsessive Compulsive Disorder (OCD) in children and adolescents over many years, manifested by a highly reputed clinical program, small grant support and original scientific publications. The Candidate is seeking the support of a Mentored Clinical Scientist Development Award in order to undertake a comprehensive program of didactic and mentored training and clinical research using the proposed research plan as a vehicle for scientific development. The Candidate is in an outstanding environment for this purpose and has assembled a highly qualified group of consultants who are leaders in their field and who are dedicated to the Candidate's research career success. The scientific development plan proposed includes training in Clinical Research Methods in Child Psychiatry-20 percent, Clinical Research Methods in Adults with Obsessive Compulsive and Related Disorders-10 percent, and courses at the Harvard School of Public Health in epidemiology and biostatistics which comprise the Formal Didactic Training-10 percent. The Candidate's background, scientific biography, research objectives and career goals reveal a clear and constant trajectory and a coherent plan for a career studying OCD in the pediatric population. The rationale for the Candidate's proposed Research Plan-35 percent, derives from the premise that OCD is very likely a heterogeneous disorder and further, that an understanding of this etiologic heterogeneity is important, not only for clinical purposes, but also as a fundamental step in future neurobiological research. The Candidate contends, using his own work and the reviewed literature, that age at onset of OCD represents the most compelling variable to study to examine etiologic heterogeneity because OCD which begins in childhood differs in important ways from the adult-onset disorder. To this end, the Candidate proposes to test several competing hypotheses to determine whether the childhood-onset form of OCD is the same or different from adult-onset OCD by studying the clinical correlates and familial aggregation of psychiatric disorders in 100 juvenile OCD probands, 50 adult OCD probands with juvenile-onset OCD and 50 adult OCD probands with adult-onset OCD and their first degree relatives. By providing data that are independent from findings in the proband, family-genetic data provide a powerful method to investigate whether juvenile-onset OCD is a clinically meaningful subtype of OCD. The clinical, scientific, and public health relevance of confirming or refuting these hypotheses is discussed.

该申请代表了研究和培训的综合计划，该计划将使候选人能够获得必要的技能，使其成为独立的临床研究者。 该候选人表现出了多年来在儿童和青少年的强迫症（OCD）领域追求临床卓越和原始研究的承诺，这表现为备受赞誉的临床计划，小的赠款支持和原始科学出版物。 该候选人正在寻求指导的临床科学家发展奖的支持，以便使用拟议的研究计划作为科学发展的工具，对教学和指导的培训和临床研究进行全面的计划。候选人为此目的是一个杰出的环境，并组建了一群高素质的顾问，他们是该领域的领导者，并致力于候选人的研究职业成功。 拟议的科学发展计划包括对儿童精神病学-20％的临床研究方法的培训，具有强迫性和相关疾病的成年人的临床研究方法，以及哈佛大学公共卫生学院流行病学和生物统计学的课程，占正式教学训练10％的正式教学培训。 候选人的背景，科学传记，研究目标和职业目标揭示了针对儿科人群研究强迫症的职业生涯的清晰轨迹和连贯的计划。候选人提议的研究计划的基本原理源于这样的前提：强迫症很可能是一种异质性疾病，进一步的理解是对这种病因学异质性的理解不仅重要，不仅对临床目的，而且是未来神经生物学研究的基本步骤。 候选人使用自己的工作和审查的文献认为，OCD发作时的年龄是研究病因异质性的最引人注目的变量，因为OCD在儿童期开始于与成人障碍的重要方式不同。 为此，候选人提议通过研究100个少年OCD概率的100个少年OCD概率的临床相关性和家族性疾病的临床相关性和家族性疾病的临床相关性和家族性聚集，与成人OCD相关性OCD和50个成人OCD相关性OCD和50名成人OCD和50名成人OCD的临床相关性和家族性疾病，以确定OCD儿童发作的形式与成人发作的OCD相同或不同。 通过提供独立于概率发现的数据，家庭基因数据提供了一种强大的方法来研究少年发作的OCD是否是OCD的临床有意义的亚型。 讨论了确认或反驳这些假设的临床，科学和公共卫生相关性。